T-B+ severe combined immunodeficiency

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Subtype of: Jak3 deficiency
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Pathways column key: KEGG Reactome
Disease Term Disease ID Gene Symbol Classification References Source Pathways
T-B+ severe combined immunodeficiency due to JAK3 deficiency
MONDO_0010938
JAK3 Causal
10982185 11741532 14615376 17344846 7481768 7659163 9354668 9753072
ClinGen, Open Targets
All17 Causal1 Unknown17
Related Diseases Diseases that share the most curated genes with T-B+ severe combined immunodeficiency.
5 View disease cluster →
T-B- severe combined immunodeficiency 5 shared genesLIG4, RAG1, RAC2, RAG2, DCLRE1C Related via 5 shared genes including LIG4, RAG1, RAC2. Omenn syndrome 7 shared genesLIG4, JAK3, IL7R, PTPRC, RAG1, RAG2, DCLRE1C Related via 7 shared genes including LIG4, JAK3, IL7R. Severe combined immunodeficiency 12 shared genesLIG4, PNP, JAK3, IL7R, CD3E, PTPRC, CD247, FOXN1, CD3D, RAG1, RAG2, DCLRE1C Related via 12 shared genes including LIG4, PNP, JAK3. Severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 3 shared genesIL7R, PTPRC, CD3D Related via 3 shared genes including IL7R, PTPRC, CD3D. Combined immunodeficiency 8 shared genesTBX1, LIG4, ORAI1, PNP, STIM1, STAT5B, FOXN1, RAG1 Related via 8 shared genes including TBX1, LIG4, ORAI1.