Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
superficial spreading melanoma	MONDO_0020638	PLCG1	Unknown	33024263 36219477	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	33024263 30178487	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	33024263	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS1	Unknown	33024263 26359337	Open Targets	—
		PMS2	Unknown	33024263 26359337 36219477	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	33024263	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	22197931 33024263 36219477 30178487	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLG	Unknown	33024263 36219477 26359337	Open Targets	Base excision repair
		POLQ	Unknown	33024263 36219477 30178487 26359337	Open Targets	HDR through MMEJ (alt-NHEJ)
		POLR2A	Unknown	36219477 26359337	Open Targets	RNA polymerase Nucleotide excision repair Huntington disease +25 more
		POT1	Unknown	33024263 26359337 36219477	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		POU2AF1	Unknown	33024263 26359337	Open Targets	—
		POU5F1	Unknown	33024263	Open Targets	Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation +1 more
		PPARG	Unknown	33024263 30178487	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPFIBP1	Unknown	33024263 26359337 30178487	Open Targets	Receptor-type tyrosine-protein phosphatases
		PPM1D	Unknown	33024263 36219477	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	33024263 36219477 30178487	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	33024263 36219477 26359337	Open Targets	COPII-mediated vesicle transport
		PRCC	Unknown	33024263 30178487	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	33024263 36219477 30178487 26359337	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	33024263 26359337 30178487	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	33024263 26359337 30178487 36219477	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	33024263 36219477 30178487 22197931 22622578 26359337 28356599	Open Targets	Regulation of PTEN stability and activity
		PRF1	Unknown	33024263	Open Targets	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PRKAR1A	Unknown	33024263 36219477 30178487	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKCB	Unknown	33024263 26359337	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	33024263 26359337	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRPF40B	Unknown	33024263 26359337 30178487	Open Targets	Spliceosome
		PSIP1	Unknown	36219477	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	33024263 36219477 30178487 26359337	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	33024263 36219477 30178487 20544847 26359337 15195137 11297763 28356599	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	33024263 36219477	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	33024263 26359337	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPN6	Unknown	33024263	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		PTPRB	Unknown	33024263 36219477 30178487	Open Targets	Adherens junction Neutrophil degranulation
		PTPRC	Unknown	33024263 26359337 30178487	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	33024263 36219477 30178487 26359337	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	22197931 33024263 36219477 30178487	Open Targets	EGFR downregulation
		PTPRT	Unknown	33024263 26359337 30178487	Open Targets	—
		PWWP2A	Unknown	33024263	Open Targets	—
		QKI	Unknown	36219477	Open Targets	Signaling by BRAF and RAF fusions
		RABEP1	Unknown	33024263	Open Targets	Endocytosis TBC/RABGAPs
		RAC1	Unknown	25043693 33024263 36219477 28356599	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +89 more
		RAD17	Unknown	33024263 26359337 30178487	Open Targets	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends +3 more
		RAD21	Unknown	33024263 26359337 36219477	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD50	Unknown	33024263 26359337	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51B	Unknown	33024263	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAD51C	Unknown	33024263 36219477 26359337	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAD51D	Unknown	33024263 30178487	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAF1	Unknown	33024263 36219477 30178487	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more

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Superficial spreading melanoma

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