Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
spindle cell intraocular melanoma	MONDO_0003744	AKT1	Unknown	23793026	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ARID2	Unknown	23793026	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ATM	Unknown	37803816	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATRX	Unknown	37803816	Open Targets	Cell cycle
		AXIN1	Unknown	26683228	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BAP1	Unknown	23793026 24423917 37803816 23861464 27015033 26683228 21051595 30480620 36077643	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BRAF	Unknown	17962436 18985043	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	37803816	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD4	Unknown	26683228	Open Targets	—
		CARS1	Unknown	23793026	Open Targets	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		CHEK2	Unknown	37803816	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CTNND2	Unknown	23793026	Open Targets	Wnt signaling pathway
		CYLD	Unknown	26683228	Open Targets	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation +9 more
		CYSLTR2	Unknown	23793026	Open Targets	Calcium signaling pathway Neuroactive ligand-receptor interaction Glucagon signaling in metabolic regulation +6 more
		DICER1	Unknown	23793026 26683228 37803816	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		EIF1AX	Unknown	37803816 26683228 23793026	Open Targets	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits +3 more
		EPHA3	Unknown	37803816	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EZR	Unknown	23793026	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FANCA	Unknown	26683228	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAT4	Unknown	23861464	Open Targets	Hippo signaling pathway - multiple species
		FBXW7	Unknown	23793026	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR4	Unknown	37803816	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		GNA11	Unknown	22569040 23793026 23456173 24423917 37803816 23861464 26683228 25756553 30480620 36077643	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		GNAQ	Unknown	22569040 23793026 27745836 24423917 31426461 37803816 23861464 28248732 26683228 27915441 25756553 30480620	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GPC3	Unknown	26683228	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		HEY1	Unknown	23793026	Open Targets	Notch signaling pathway Human papillomavirus infection Pathways in cancer +4 more
		ID3	Unknown	23793026	Open Targets	TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells NGF-stimulated transcription
		LRP1B	Unknown	37803816	Open Targets	—
		MITF	Unknown	23793026	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLLT1	Unknown	23793026	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MTOR	Unknown	23793026 37803816	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC4	Unknown	23861464	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		NUMA1	Unknown	23861464	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		PABPC1	Unknown	23793026	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PAX5	Unknown	23793026	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PIK3R3	Unknown	23793026	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PLEC	Unknown	23793026	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		POLE	Unknown	26683228	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PRDM2	Unknown	23793026	Open Targets	Lysine degradation Metabolic pathways
		PTK6	Unknown	26683228	Open Targets	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling +8 more
		PTPRD	Unknown	37803816	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		RASA1	Unknown	23793026	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		SDC4	Unknown	23793026	Open Targets	ECM-receptor interaction Cell adhesion molecules Cytoskeleton in muscle cells +13 more
		SF3B1	Unknown	23793026 24423917 37803816 23861464 26683228 27745836 30480620	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SND1	Unknown	26683228	Open Targets	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SRSF2	Unknown	31426461	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		TBX3	Unknown	37803816	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TERT	Unknown	23793026	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TMSB4X	Unknown	23793026	Open Targets	Regulation of actin cytoskeleton Platelet degranulation
		TSC2	Unknown	37803816	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more

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Spindle cell intraocular melanoma

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