Spinal muscular atrophy

Viral life cycle - HIV-1 COPI-independent Golgi-to-ER retrograde traffic

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation +21 more

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation +21 more

snRNP Assembly

snRNP Assembly

Cytoskeleton in muscle cells PPARA activates gene expression

Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation Prostate cancer HSP90 chaperone cycle for steroid hormone receptors (SHR) Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases RUNX2 regulates osteoblast differentiation +7 more

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

snRNP Assembly

Other glycan degradation Various types of N-glycan biosynthesis Amino sugar and nucleotide sugar metabolism Glycosaminoglycan degradation Sphingolipid metabolism Glycosphingolipid biosynthesis - globo and isoglobo series Glycosphingolipid biosynthesis - ganglio series Metabolic pathways Lysosome Glycosphingolipid metabolism Keratan sulfate degradation CS/DS degradation Hyaluronan uptake and degradation Defective HEXB causes GM2G2 Neutrophil degranulation +12 more

snRNP Assembly

Spliceosome mRNA Splicing - Major Pathway

Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils +1 more

Cellular senescence Inflammatory mediator regulation of TRP channels Fluid shear stress and atherosclerosis TRP channels +1 more

Cholesterol metabolism Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Sphingolipid de novo biosynthesis +1 more

snRNP Assembly

Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway Lysosome Glycosphingolipid metabolism Neutrophil degranulation +3 more

Major pathway of rRNA processing in the nucleolus and cytosol

Viral life cycle - HIV-1 COPI-independent Golgi-to-ER retrograde traffic

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation +21 more

Pathways in cancer NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events +1 more

Cytokine-cytokine receptor interaction TNFs bind their physiological receptors

Cellular senescence Inflammatory mediator regulation of TRP channels Fluid shear stress and atherosclerosis TRP channels +1 more

Platinum drug resistance Mineral absorption Ion influx/efflux at host-pathogen interface Ion transport by P-type ATPases +1 more

NOD-like receptor signaling pathway Pathogenic Escherichia coli infection Shigellosis Salmonella infection Legionellosis +2 more

snRNP Assembly

snRNP Assembly

Protein processing in endoplasmic reticulum

MAPK signaling pathway VEGF signaling pathway Amoebiasis VEGFA-VEGFR2 Pathway AUF1 (hnRNP D0) binds and destabilizes mRNA MAPK6/MAPK4 signaling Extra-nuclear estrogen signaling +4 more

HSF1-dependent transactivation

Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases

Amyotrophic lateral sclerosis

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Cholesterol metabolism Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Sphingolipid de novo biosynthesis +1 more

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation +21 more

Viral life cycle - HIV-1 COPI-independent Golgi-to-ER retrograde traffic

Oxidative phosphorylation Metabolic pathways Thermogenesis Retrograde endocannabinoid signaling Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Respiratory electron transport Complex I biogenesis +11 more

snRNP Assembly

snRNP Assembly

snRNP Assembly

snRNP Assembly

snRNP Assembly

Ubiquitin mediated proteolysis Parkinson disease Pathways of neurodegeneration - multiple diseases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation +2 more