Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
spinal cord astrocytoma	MONDO_0003174	ABL2	Unknown	26487540	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ARID1A	Unknown	36672991	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ATM	Unknown	26487540	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATRX	Unknown	26487540	Open Targets	Cell cycle
		BMPR1A	Unknown	26487540	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +4 more
		BRAF	Unknown	25909089	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CARD11	Unknown	36672991	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CDK4	Unknown	36672991	Open Targets	Endocrine resistance Cell cycle p53 signaling pathway +40 more
		CDK6	Unknown	36672991	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +27 more
		CDKN1A	Unknown	26487540	Open Targets	Endocrine resistance Platinum drug resistance ErbB signaling pathway +56 more
		CREBBP	Unknown	36672991	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CTNNB1	Unknown	36672991	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		EGFR	Unknown	36672991	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ERBB2	Unknown	26487540	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		FANCA	Unknown	26487540	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FLCN	Unknown	26487540	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		H3-3A	Unknown	23592488 25200322 25479829 25909089 26231952 26487540 27236270 28447171 28966033 35456430	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more
		HLA-A	Unknown	26487540	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HSP90AA1	Unknown	26487540	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		HSP90AB1	Unknown	26487540	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		KIAA1549	Unknown	25909089	Open Targets	Signaling by BRAF and RAF fusions
		KMT2C	Unknown	26487540	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		MET	Unknown	36672991	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MTOR	Unknown	36672991	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		NF1	Unknown	35456430 36672991	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFE2L2	Unknown	26487540	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NOTCH2	Unknown	26487540	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	26487540	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		PER1	Unknown	26487540	Open Targets	Circadian rhythm Circadian entrainment
		PIK3R1	Unknown	30333046	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PRDM1	Unknown	26487540	Open Targets	Regulation of TP53 Expression
		PTEN	Unknown	36672991	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN13	Unknown	26487540	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		RAD51C	Unknown	36672991	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RB1	Unknown	36672991	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	26487540	Open Targets	—
		RNF213	Unknown	26487540	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		SDHA	Unknown	26487540	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SSX1	Unknown	26487540	Open Targets	Transcriptional misregulation in cancer
		TENT5C	Unknown	26487540	Open Targets	—
		TNFRSF14	Unknown	26487540	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TP53	Unknown	25909089 9210874 26487540 23592488 36672991	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more

Spinal cord astrocytoma

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