Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
small intestine adenocarcinoma	MONDO_0003198	ERBB4	Unknown	35778698 25695693 26315110	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERCC3	Unknown	28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	28481359	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ETV1	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer
		EWSR1	Unknown	26764183	Open Targets	Transcriptional misregulation in cancer
		EZH2	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FAM131B	Unknown	30239619	Open Targets	Signaling by BRAF and RAF fusions
		FAT4	Unknown	30239619 26764183	Open Targets	Hippo signaling pathway - multiple species
		FBXO11	Unknown	19852062 28481359 25478808	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	35778698 24797764 28481359 26315110	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FLCN	Unknown	28481359	Open Targets	mTOR signaling pathway Renal cell carcinoma Amino acids regulate mTORC1
		FLT4	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		GNAS	Unknown	35778698 28481359	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GSK3B	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		HLA-A	Unknown	28481359	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HNF1A	Unknown	28481359	Open Targets	Maturity onset diabetes of the young
		HOXA11	Unknown	27900363	Open Targets	Transcriptional misregulation in cancer
		IDH1	Unknown	25029120 28481359 37988281 26315110	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	28481359	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	28481359	Open Targets	—
		KDM5A	Unknown	28481359	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	28481359	Open Targets	HDMs demethylate histones
		KDR	Unknown	24797764 26315110	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KEAP1	Unknown	30717682 27900363	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIT	Unknown	35778698 26315110	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2C	Unknown	30352910 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	30352910 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	15513360 25478808 25759539 26764183 27900363 21704278 24797764 26892442 26315110 9033644 35778698 11117578 30239619 25695693 22178590 30717682 9658320 9592195 9207270 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		MAP2K1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP3K1	Unknown	30239619 28481359	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MED12	Unknown	28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	28481359	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	28481359 26315110	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLLT11	Unknown	30239619	Open Targets	—
		MSH2	Unknown	28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	19852062 28481359 25478808	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MYCN	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer
		MYH11	Unknown	30239619	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYO5A	Unknown	26764183 27900363	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		NBEA	Unknown	27900363	Open Targets	—
		NBN	Unknown	28481359	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more
		NCOA1	Unknown	27900363	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NCOR1	Unknown	28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFATC2	Unknown	27900363	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NKX2-1	Unknown	28481359	Open Targets	—
		NOTCH1	Unknown	35778698 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more

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Small intestine adenocarcinoma

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