Sleep apnea

Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways ABO blood group biosynthesis +1 more

Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Striated Muscle Contraction

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance NF-kappa B signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway p53 signaling pathway Autophagy - animal Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Adrenergic signaling in cardiomyocytes Hedgehog signaling pathway Focal adhesion NOD-like receptor signaling pathway JAK-STAT signaling pathway Neurotrophin signaling pathway Cholinergic synapse Estrogen signaling pathway Parathyroid hormone synthesis, secretion and action AGE-RAGE signaling pathway in diabetic complications Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Salmonella infection Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Prostate cancer Small cell lung cancer Gastric cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +46 more

MAPK signaling pathway Ras signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Huntington disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Alcoholism Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through FRS2 and FRS3 NTRK2 activates RAC1 +9 more

Transcriptional misregulation in cancer Prostate cancer

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Regulation of actin cytoskeleton Pathways in cancer Chemical carcinogenesis - receptor activation Melanoma Breast cancer Gastric cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer +38 more

Reversal of alkylation damage by DNA dioxygenases

Polycomb repressive complex HDMs demethylate histones

Signaling pathways regulating pluripotency of stem cells Transcriptional misregulation in cancer

Protein repair

TGF-beta signaling pathway Signaling by BMP

Insulin signaling pathway Insulin resistance

Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO

COPII-mediated vesicle transport

Axon guidance Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling +1 more

Rap1 signaling pathway

Ferroptosis Alzheimer disease Parkinson disease Zinc influx into cells by the SLC39 gene family +1 more

Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin

Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction Thermogenesis Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy TP53 Regulates Metabolic Genes Respiratory electron transport +12 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway Pathogenic Escherichia coli infection Shigellosis Salmonella infection Legionellosis Yersinia infection African trypanosomiasis Malaria Tuberculosis Influenza A Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection +18 more

Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels

Glycerophospholipid metabolism Cholinergic synapse Synthesis of PC Acetylcholine Neurotransmitter Release Cycle +1 more

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Gap junction Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +12 more

MAPK signaling pathway Ras signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway Neurotrophin signaling pathway Huntington disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Alcoholism Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through FRS2 and FRS3 NTRK2 activates RAC1 +9 more

Classical antibody-mediated complement activation

cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction TNF signaling pathway Melanogenesis Renin secretion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis Peptide ligand-binding receptors G alpha (q) signalling events +11 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction Renin secretion Pathways in cancer Peptide ligand-binding receptors G alpha (q) signalling events +6 more

Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling AMPK signaling pathway JAK-STAT signaling pathway Adipocytokine signaling pathway Non-alcoholic fatty liver disease +4 more

Endocrine resistance IL-17 signaling pathway TNF signaling pathway Leukocyte transendothelial migration Estrogen signaling pathway Relaxin signaling pathway Hepatitis B Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Bladder cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Signaling by SCF-KIT Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling +22 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apelin signaling pathway Platelet activation Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling +24 more

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +18 more

Synaptic vesicle cycle Serotonergic synapse Serotonin clearance from the synaptic cleft

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway Sphingolipid signaling pathway mTOR signaling pathway Apoptosis Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer Asthma Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Hypertrophic cardiomyopathy Dilated cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling +72 more