Sclerosing cholangitis

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

Purine metabolism Metabolic pathways Endocrine resistance Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Longevity regulating pathway Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Thermogenesis Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse GABAergic synapse Olfactory transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Morphine addiction Vibrio cholerae infection Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +61 more

Th17 cell differentiation Cushing syndrome Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling +6 more

NOD-like receptor signaling pathway Uptake and function of anthrax toxins

Endocytosis Fc gamma R-mediated phagocytosis

Autophagy - other Autophagy - animal NOD-like receptor signaling pathway Shigellosis Macroautophagy +2 more

Autophagy - other Autophagy - animal Longevity regulating pathway Longevity regulating pathway - multiple species Ferroptosis NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Shigellosis Macroautophagy Pink/Parkin Mediated Mitophagy Receptor Mediated Mitophagy +8 more

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

B cell receptor signaling pathway

NF-kappa B signaling pathway Apoptosis Transcriptional misregulation in cancer Acute myeloid leukemia +1 more

NOD-like receptor signaling pathway C-type lectin receptor signaling pathway Tuberculosis Herpes simplex virus 1 infection CLEC7A (Dectin-1) signaling +2 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NOD-like receptor signaling pathway IL-17 signaling pathway TNF signaling pathway AGE-RAGE signaling pathway in diabetic complications Yersinia infection Chagas disease Malaria Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Rheumatoid arthritis Lipid and atherosclerosis Fluid shear stress and atherosclerosis Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling +18 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway IL-17 signaling pathway TNF signaling pathway Rheumatoid arthritis Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling +6 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway Chemokine receptors bind chemokines G alpha (i) signalling events +3 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events +3 more

Cell adhesion molecules Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Natural killer cell mediated cytotoxicity Cell surface interactions at the vascular wall

Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production Type I diabetes mellitus Measles PD-L1 expression and PD-1 checkpoint pathway in cancer Autoimmune thyroid disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer CD28 co-stimulation CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +16 more

Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Cell adhesion molecules Toll-like receptor signaling pathway Intestinal immune network for IgA production Malaria Toxoplasmosis Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Transcriptional misregulation in cancer Asthma Autoimmune thyroid disease Systemic lupus erythematosus Allograft rejection Primary immunodeficiency Viral myocarditis Lipid and atherosclerosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway +17 more

Cell adhesion molecules

tRNA modification in the nucleus and cytosol

Formation of the cornified envelope

Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2 +6 more

Complement and coagulation cascades Staphylococcus aureus infection Coronavirus disease - COVID-19 Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade +3 more

Neddylation

Phagosome Tuberculosis Prevention of phagosomal-lysosomal fusion

Oocyte meiosis Progesterone-mediated oocyte maturation

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Regulation of FOXO transcriptional activity by acetylation +52 more

Adrenergic signaling in cardiomyocytes

Cell adhesion molecules T cell receptor signaling pathway Autoimmune thyroid disease Rheumatoid arthritis CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) +3 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Phospholipase D signaling pathway Endocytosis Epithelial cell signaling in Helicobacter pylori infection Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation +6 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Phospholipase D signaling pathway Endocytosis Epithelial cell signaling in Helicobacter pylori infection Human cytomegalovirus infection Chemokine receptors bind chemokines G alpha (i) signalling events Neutrophil degranulation +7 more

RAB GEFs exchange GTP for GDP on RABs

Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Glycine, serine and threonine metabolism Valine, leucine and isoleucine degradation Lysine degradation Tryptophan metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism Propanoate metabolism One carbon pool by folate Lipoic acid metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of cofactors Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Glycine degradation Pyruvate metabolism Branched-chain amino acid catabolism Lysine catabolism Citric acid cycle (TCA cycle) +20 more

Cysteine and methionine metabolism Metabolic pathways Efferocytosis MicroRNAs in cancer PRC2 methylates histones and DNA RMTs methylate histone arginines +3 more

Cysteine and methionine metabolism Metabolic pathways MicroRNAs in cancer PRC2 methylates histones and DNA SUMOylation of DNA methylation proteins +2 more

NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production