Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Richter transformation	MONDO_0002083	NF1	Unknown	35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFATC2	Unknown	35953718	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Efferocytosis +24 more
		NFE2L2	Unknown	35953718	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFIB	Unknown	35953718	Open Targets	—
		NFKBIE	Unknown	35953718 33206936	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NIN	Unknown	35953718	Open Targets	—
		NOTCH1	Unknown	30508305 22077063 35953718 24127483 27686521 23243274 33206936 21670202	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	35953718 24127483	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	35953718	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD2	Unknown	35953718	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NT5C2	Unknown	35953718	Open Targets	Purine metabolism Pyrimidine metabolism Nicotinate and nicotinamide metabolism +4 more
		NTRK1	Unknown	35953718	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	35953718 24127483	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		NTRK3	Unknown	35953718	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	35953718	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP98	Unknown	35953718	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		P2RY8	Unknown	35953718	Open Targets	Neuroactive ligand-receptor interaction
		PALB2	Unknown	35953718	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PAX3	Unknown	35953718	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	35953718 24127483	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	35953718	Open Targets	Transcriptional misregulation in cancer
		PBRM1	Unknown	35953718	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	35953718	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCM1	Unknown	35953718	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDCD1LG2	Unknown	35953718	Open Targets	Cell adhesion molecules PD-1 signaling
		PDE4DIP	Unknown	35953718	Open Targets	—
		PDGFRB	Unknown	35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PER1	Unknown	33206936	Open Targets	Circadian rhythm Circadian entrainment
		PICALM	Unknown	35953718	Open Targets	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		PIK3CB	Unknown	35953718	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PIK3R3	Unknown	35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PIM1	Unknown	24127483	Open Targets	JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer +3 more
		PLAG1	Unknown	35953718	Open Targets	—
		PLCG1	Unknown	35953718	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	35953718	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	35953718	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS1	Unknown	35953718	Open Targets	—
		PMS2	Unknown	35953718	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLE	Unknown	35953718	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POT1	Unknown	35953718 24127483	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		POU2AF1	Unknown	35953718	Open Targets	—
		PPFIBP1	Unknown	35953718	Open Targets	Receptor-type tyrosine-protein phosphatases
		PPP2R1A	Unknown	35953718	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	35953718	Open Targets	COPII-mediated vesicle transport
		PRDM1	Unknown	35953718	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	35953718	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	35953718	Open Targets	Lysine degradation Metabolic pathways

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Richter transformation

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