Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Richter transformation	MONDO_0002083	PREX2	Unknown	35953718 24127483	Open Targets	Regulation of PTEN stability and activity
		PRKAR1A	Unknown	35953718	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKCB	Unknown	33206936 35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	35953718	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRPF40B	Unknown	35953718	Open Targets	Spliceosome
		PTEN	Unknown	35953718	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	35953718	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	35953718	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPRB	Unknown	35953718	Open Targets	Adherens junction Neutrophil degranulation
		PTPRD	Unknown	35953718 33206936	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	35953718	Open Targets	EGFR downregulation
		PTPRT	Unknown	35953718	Open Targets	—
		QKI	Unknown	35953718	Open Targets	Signaling by BRAF and RAF fusions
		RAC1	Unknown	35953718	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +89 more
		RAD51B	Unknown	35953718	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAF1	Unknown	35953718	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RANBP2	Unknown	35953718	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1B	Unknown	35953718	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +25 more
		RASA1	Unknown	35953718	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	33206936 24127483	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RFWD3	Unknown	35953718	Open Targets	—
		RGPD3	Unknown	35953718	Open Targets	—
		RGS7	Unknown	35953718	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOH	Unknown	35953718	Open Targets	Leukocyte transendothelial migration Salmonella infection Rho GTPase cycle
		RICTOR	Unknown	35953718	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RNF213	Unknown	35953718	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		ROBO2	Unknown	35953718	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROCK1	Unknown	35953718	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		ROS1	Unknown	35953718	Open Targets	—
		RPN1	Unknown	35953718	Open Targets	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +2 more
		RRAS2	Unknown	35953718	Open Targets	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +8 more
		RSPO2	Unknown	35953718	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		RSPO3	Unknown	35953718	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling
		RUNX1T1	Unknown	35953718	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SDHAF2	Unknown	35953718	Open Targets	—
		SDHB	Unknown	35953718	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SDHD	Unknown	35953718	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SEPTIN6	Unknown	35953718	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SEPTIN9	Unknown	35953718	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETBP1	Unknown	35953718	Open Targets	—
		SETD1B	Unknown	35953718	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SETD2	Unknown	33206936 35953718	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	35953718	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SF3B1	Unknown	30508305 35953718 24127483 23243274 33206936 24920063 22039264	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SGK1	Unknown	35953718	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SH2B3	Unknown	35953718	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SHTN1	Unknown	35953718	Open Targets	—
		SIRPA	Unknown	35953718	Open Targets	Efferocytosis Osteoclast differentiation Cell surface interactions at the vascular wall +2 more
		SIX2	Unknown	35953718	Open Targets	—
		SLC34A2	Unknown	24127483	Open Targets	Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters +2 more

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Richter transformation

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