Retinitis pigmentosa

Hedgehog 'off' state Anchoring of the basal body to the plasma membrane

Phototransduction Inactivation, recovery and regulation of the phototransduction cascade

Central carbon metabolism in cancer TP53 Regulates Metabolic Genes Respiratory electron transport

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +4 more

Axon guidance Other semaphorin interactions

Spliceosome mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway

Vitamin digestion and absorption Vitamin B1 (thiamin) metabolism

Phototransduction Sodium/Calcium exchangers Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)

Alzheimer disease Parkinson disease

Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Steroid hormone biosynthesis N-Glycan biosynthesis Metabolic pathways Androgen biosynthesis Synthesis of Dolichyl-phosphate Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ +3 more

Hippo signaling pathway Hippo signaling pathway - multiple species YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination +2 more

Proteoglycans in cancer MicroRNAs in cancer Platelet degranulation

Anchoring of the basal body to the plasma membrane

SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins

Intraflagellar transport

Cytosolic DNA-sensing pathway Regulation by TREX1 IRF3-mediated induction of type I IFN

Ubiquitin mediated proteolysis Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation

tRNA processing in the nucleus tRNA processing in the mitochondrion

Carboxyterminal post-translational modifications of tubulin

Phagosome Gap junction Motor proteins Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins +38 more

Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes

Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes

Polycomb repressive complex Formation of Incision Complex in GG-NER

Cell adhesion molecules Cytoskeleton in muscle cells A tetrasaccharide linker sequence is required for GAG synthesis Chondroitin sulfate biosynthesis Dermatan sulfate biosynthesis CS/DS degradation ECM proteoglycans Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective CHST14 causes EDS, musculocontractural type Defective CHSY1 causes TPBS Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Defective B3GALT6 causes EDSP2 and SEMDJL1 Post-translational protein phosphorylation +12 more

Protein processing in endoplasmic reticulum XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more

Hippo signaling pathway Hippo signaling pathway - multiple species YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription +1 more

Glycolysis / Gluconeogenesis Citrate cycle (TCA cycle) Pyruvate metabolism Metabolic pathways PPAR signaling pathway FoxO signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Insulin signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Proximal tubule bicarbonate reclamation Gluconeogenesis +11 more

Hedgehog 'off' state Anchoring of the basal body to the plasma membrane