Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	NUTM2D	Unknown	33262464	Open Targets	—
		OLIG2	Unknown	30239619 33262464 25957691	Open Targets	—
		OMD	Unknown	33262464	Open Targets	Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 +2 more
		P2RY8	Unknown	22810696 33262464 25344691 31660073	Open Targets	Neuroactive ligand-receptor interaction
		PABPC1	Unknown	22810696 26109429 30239619 33262464 25344691	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PAFAH1B2	Unknown	33262464 31660073	Open Targets	Ether lipid metabolism Metabolic pathways Neutrophil degranulation +1 more
		PALB2	Unknown	33262464 26416732 29316426 25344691 26764183 28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PATZ1	Unknown	22810696 26416732 25344691 31660073	Open Targets	—
		PAX3	Unknown	26416732 33262464 25344691 29937994	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX5	Unknown	26416732 33262464 28481359	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	30239619 33262464 26416732 29937994	Open Targets	Transcriptional misregulation in cancer
		PAX8	Unknown	24755471 26416732 33262464 31660073	Open Targets	Thyroid hormone synthesis Pathways in cancer Transcriptional misregulation in cancer +1 more
		PBRM1	Unknown	29967250 24943349 33262464 26416732 29316426 28465371 31660073 25344691 24755471 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PBX1	Unknown	30038269 26109429 31660073	Open Targets	Efferocytosis Cortisol synthesis and secretion Cushing syndrome +3 more
		PCBP1	Unknown	22810696 31660073 24943349 25344691 29937994	Open Targets	Spliceosome Ferroptosis Cytosolic DNA-sensing pathway +2 more
		PCM1	Unknown	22810696 33262464 25344691 26764183 31660073	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDE4DIP	Unknown	22810696 26416732 25957691 31660073 26109429 25344691	Open Targets	—
		PDGFB	Unknown	31660073 27612425	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PDGFRA	Unknown	22810696 33262464 26416732 29316426 27756406 31660073 26968814 25617745 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	29316426 33262464 28481359 31660073	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PER1	Unknown	31660073 26416732 33262464 29937994	Open Targets	Circadian rhythm Circadian entrainment
		PHF6	Unknown	33262464	Open Targets	ATP-dependent chromatin remodeling
		PHOX2B	Unknown	22810696 24755471 33262464 28481359	Open Targets	—
		PIK3CA	Unknown	18602395 26650777 27612425 26416732 29316426 27121310 26134512 24755471 21726664 22810696 29967250 19731079 22586484 29069792 21103049 19223544 31660073 36212424 31400926 29937994 25957691 28465371 18022911 22357840 22392911 22617127 25344691 24676216 26764183 22553375 28551381 33262464 29438965 22586653 24841357 28978093 30239619 25617745 22753589 28481359 19903786 17932254	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	26416732 29316426 28481359 31660073	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	22810696 33262464 29937994 26416732 29316426 28465371 31660073 28481359 31226844	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PIK3R2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		PIK3R3	Unknown	29316426 33262464 31660073	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PIM1	Unknown	33262464 31660073	Open Targets	JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer +3 more
		PLAG1	Unknown	26416732 33262464	Open Targets	—
		PLCG1	Unknown	24755471 33262464 25344691 29937994	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	22810696 33262464 29937994 26416732 25957691 31660073 25344691 24755471 26764183	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PML	Unknown	22810696 29967250 33262464 29937994 25957691 31660073 25344691	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS1	Unknown	24755471 26416732 29316426 28481359	Open Targets	—
		PMS2	Unknown	22810696 26416732 29316426 31660073 26109429 28978093 28481359	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	29316426 30038269 26416732 33262464 31660073	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	22810696 21157497 26416732 29316426 28465371 31660073 27022117 28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLG	Unknown	22810696 33262464	Open Targets	Base excision repair
		POLQ	Unknown	22810696 33262464 29937994 26416732 31660073 25344691 24755471	Open Targets	HDR through MMEJ (alt-NHEJ)
		POLR2A	Unknown	22810696	Open Targets	RNA polymerase Nucleotide excision repair Huntington disease +25 more
		POT1	Unknown	33262464 31660073	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		POU2AF1	Unknown	26416732	Open Targets	—
		POU5F1	Unknown	31660073 25344691 27612425	Open Targets	Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation +1 more
		PPFIBP1	Unknown	22810696 26416732 31660073	Open Targets	Receptor-type tyrosine-protein phosphatases
		PPM1D	Unknown	28481359 29937994 27612425	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	29316426 26416732 33262464 28481359 29937994	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	33262464	Open Targets	COPII-mediated vesicle transport
		PRCC	Unknown	33262464 31660073	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	22810696 33262464 28465371 31660073 30239619 28481359	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	22810696 33262464 29937994 25344691 24755471 26764183	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more

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Rectum adenocarcinoma

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