Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pulmonary blastoma	MONDO_0005933	A1CF	Unknown	24909177	Open Targets	mRNA Editing: C to U Conversion Formation of the Editosome
		AKT1	Unknown	32291395	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ALK	Unknown	27877056 28624956 32291395	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AR	Unknown	24675358	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARID1B	Unknown	24909177	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	24675358	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ATM	Unknown	24909177 32291395	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		BAP1	Unknown	29874541	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCOR	Unknown	24909177 24675358 32291395	Open Targets	Polycomb repressive complex
		BRAF	Unknown	32291395 24909177 27877056	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	27877056	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRIP1	Unknown	32291395	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +8 more
		CACNA1D	Unknown	24909177	Open Targets	MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +35 more
		CARD11	Unknown	24909177	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CEBPA	Unknown	32291395	Open Targets	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		CIC	Unknown	32291395	Open Targets	Spinocerebellar ataxia
		CNBD1	Unknown	24909177	Open Targets	—
		CNTNAP2	Unknown	24675358	Open Targets	Cell adhesion molecules
		CSMD3	Unknown	24909177	Open Targets	—
		CTNNB1	Unknown	17350138 11464291 12754743 15223963 29874541 27126690 21292787 22705117 24675358	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DICER1	Unknown	31603374 24513630 24909177 28624956 29874541 27126690 26928971 24675358 26925222 23868280 26475046 32291395	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		EGFR	Unknown	27877056 21292787 24909177 28624956 32291395	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ERBB4	Unknown	27877056	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ETV6	Unknown	10658907	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		FAM135B	Unknown	24909177 24675358	Open Targets	—
		FANCD2	Unknown	32291395	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FAT1	Unknown	32291395	Open Targets	—
		FAT4	Unknown	24909177	Open Targets	Hippo signaling pathway - multiple species
		FOXA1	Unknown	28624956	Open Targets	Estrogen-dependent gene expression
		GRIN2A	Unknown	24909177	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		IDH1	Unknown	32291395	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IRS4	Unknown	24909177	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		JAK1	Unknown	24909177	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAZF1	Unknown	32291395	Open Targets	—
		KAT6B	Unknown	32291395	Open Targets	HATs acetylate histones
		KMT2D	Unknown	32291395	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	22705117 32291395	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		KTN1	Unknown	24909177	Open Targets	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RHO GTPases activate KTN1 Post-translational protein phosphorylation
		MAFB	Unknown	24909177	Open Targets	Parathyroid hormone synthesis, secretion and action
		MAP2K4	Unknown	32291395	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MED12	Unknown	24909177	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MET	Unknown	32291395 27877056	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MSH2	Unknown	32291395	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MUC16	Unknown	24909177	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYH9	Unknown	24909177	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		NCOA2	Unknown	24909177 24675358	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NCOR1	Unknown	24909177	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	24675358	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NOTCH1	Unknown	32291395	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	24909177	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more

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Pulmonary blastoma

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