Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pseudomyxoma peritonei	EFO_0007456	AKAP9	Unknown	24944587	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AKT1	Unknown	26475379 27502722 25274248	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ANK1	Unknown	24944587	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		AR	Unknown	24944587	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARID1A	Unknown	24944587	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ATM	Unknown	25274248	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATR	Unknown	24944587	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		BIRC6	Unknown	24944587	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BRCA2	Unknown	24944587	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CARD11	Unknown	24944587	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CBLC	Unknown	24944587	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CDH1	Unknown	27502722	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CNTNAP2	Unknown	24944587	Open Targets	Cell adhesion molecules
		CSMD3	Unknown	24944587	Open Targets	—
		CTNNA2	Unknown	24944587	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNNB1	Unknown	27502722 24944587	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		CTNND1	Unknown	24944587	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		FAM135B	Unknown	24944587	Open Targets	—
		FAT3	Unknown	24944587	Open Targets	—
		FAT4	Unknown	24944587	Open Targets	Hippo signaling pathway - multiple species
		FEV	Unknown	24944587	Open Targets	Transcriptional misregulation in cancer
		FGFR3	Unknown	27502722 27154293	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		GNAS	Unknown	28868010 24944587 24369359 25274248 27502722 27154293 26475379	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		HGF	Unknown	24944587	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HNF1A	Unknown	27502722 27154293 24944587	Open Targets	Maturity onset diabetes of the young
		KLF4	Unknown	24944587	Open Targets	Signaling pathways regulating pluripotency of stem cells Chemical carcinogenesis - receptor activation Synthesis, secretion, and deacylation of Ghrelin +1 more
		KMT2D	Unknown	24944587	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	23199549 24944587 24369359 25274248 27502722 27154293 26475379 24951608	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		MN1	Unknown	24944587	Open Targets	—
		MSN	Unknown	24944587	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +4 more
		MUC16	Unknown	24944587	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		NOTCH2	Unknown	24944587	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	26475379	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	24944587	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		PDGFRA	Unknown	26475379 27502722	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	24944587	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PIK3CA	Unknown	26475379 27502722 25274248 24944587	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PRKACA	Unknown	24944587	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKCB	Unknown	24944587	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PTPN6	Unknown	24944587	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		RAP1B	Unknown	24944587	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +25 more
		RBM10	Unknown	24944587	Open Targets	—
		RET	Unknown	26475379	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RNF213	Unknown	24944587	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		ROBO2	Unknown	24944587	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		SEPTIN6	Unknown	24944587	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SH3GL1	Unknown	24944587	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SMAD2	Unknown	24944587	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD3	Unknown	24944587	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	26475379 27502722 25274248 24944587 28263231	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more

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Pseudomyxoma peritonei

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