Progressive external ophthalmoplegia

Base excision repair

Base excision repair Transcriptional activation of mitochondrial biogenesis

Mitochondrial transcription initiation Transcriptional activation of mitochondrial biogenesis

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism p53 signaling pathway Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes +6 more

Calcium signaling pathway cGMP-PKG signaling pathway Necroptosis Cellular senescence Neutrophil extracellular trap formation Alzheimer disease Parkinson disease Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Influenza A Human T-cell leukemia virus 1 infection Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Mitochondrial protein import Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane +15 more

Spinocerebellar ataxia Transcriptional activation of mitochondrial biogenesis

Base excision repair

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Interconversion of nucleotide di- and triphosphates +4 more

Pyrimidine metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Pyrimidine salvage +2 more

Homologous recombination Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +8 more

MAPK signaling pathway Cytokine-cytokine receptor interaction Necroptosis Cellular senescence Osteoclast differentiation Hematopoietic cell lineage Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pertussis Leishmaniasis Tuberculosis Measles Influenza A Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Fluid shear stress and atherosclerosis Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +24 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Inflammatory mediator regulation of TRP channels Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Measles Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Lipid and atherosclerosis Fluid shear stress and atherosclerosis Interleukin-1 processing CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +47 more

Base excision repair

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Interconversion of nucleotide di- and triphosphates +4 more

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism p53 signaling pathway Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes +6 more

Calcium signaling pathway cGMP-PKG signaling pathway Necroptosis Cellular senescence Neutrophil extracellular trap formation Alzheimer disease Parkinson disease Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Influenza A Human T-cell leukemia virus 1 infection Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Mitochondrial protein import Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane +15 more

Peroxisome Longevity regulating pathway - multiple species Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Platelet degranulation Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +8 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

Spinocerebellar ataxia Transcriptional activation of mitochondrial biogenesis