Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
primary central nervous system lymphoma	MONDO_0002571	MUC16	Unknown	33481259	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	24970810	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYB	Unknown	24970810	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYC	Unknown	26111727	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYD88	Unknown	28619981 25991819 22837180 33481259 26111727 24970810 25643939 22020631 26195323	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH11	Unknown	25991819	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYO5A	Unknown	25991819	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		NBEA	Unknown	25991819	Open Targets	—
		NBN	Unknown	25991819	Open Targets	Homologous recombination Cellular senescence DNA Damage/Telomere Stress Induced Senescence +13 more
		NCOA1	Unknown	25991819	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway Pathways in cancer +18 more
		NCOR2	Unknown	33481259	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NF1	Unknown	25991819	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NKX2-1	Unknown	24970810	Open Targets	—
		NONO	Unknown	24970810	Open Targets	—
		NOTCH1	Unknown	24970810	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	24970810	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NR2F2	Unknown	24970810	Open Targets	—
		NRG1	Unknown	33481259	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	33481259	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD2	Unknown	25991819	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		NTHL1	Unknown	25991819	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +3 more
		PABPC1	Unknown	25991819 24970810	Open Targets	mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression +5 more
		PALB2	Unknown	25991819	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PATZ1	Unknown	25991819	Open Targets	—
		PAX5	Unknown	25991819	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PCBP1	Unknown	25991819	Open Targets	Spliceosome Ferroptosis Cytosolic DNA-sensing pathway +2 more
		PDE4DIP	Unknown	25991819 24970810	Open Targets	—
		PIM1	Unknown	33481259 25991819 24970810	Open Targets	JAK-STAT signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer +3 more
		POLE	Unknown	25991819 24970810	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		POLG	Unknown	25991819	Open Targets	Base excision repair
		POLQ	Unknown	25991819	Open Targets	HDR through MMEJ (alt-NHEJ)
		POT1	Unknown	24970810	Open Targets	Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Packaging Of Telomere Ends +2 more
		PPFIBP1	Unknown	25991819	Open Targets	Receptor-type tyrosine-protein phosphatases
		PRDM1	Unknown	33481259 25991819 22837180 18596541 26111727	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	25991819	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRKCB	Unknown	33481259	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	24970810	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRRX1	Unknown	33481259	Open Targets	—
		PTCH1	Unknown	25991819	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTPN13	Unknown	24970810	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPRB	Unknown	25991819	Open Targets	Adherens junction Neutrophil degranulation
		PTPRK	Unknown	33481259	Open Targets	EGFR downregulation
		RAD51B	Unknown	25991819	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RALGDS	Unknown	25991819	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		RAP1GDS1	Unknown	33481259	Open Targets	—
		RBM10	Unknown	25991819	Open Targets	—
		RBM15	Unknown	25991819	Open Targets	—
		RHOA	Unknown	33481259 26111727	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RUNX1T1	Unknown	33481259 25991819	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SETBP1	Unknown	24970810	Open Targets	—

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Primary central nervous system lymphoma

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