Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
primary central nervous system lymphoma	MONDO_0002571	ACVR2A	Unknown	24970810	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		AFDN	Unknown	25991819	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF3	Unknown	33481259	Open Targets	—
		ALDH2	Unknown	33481259	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ANK1	Unknown	25991819	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		APC	Unknown	25991819	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	24970810	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARAF	Unknown	25991819	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARHGAP5	Unknown	24970810	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF10L	Unknown	25991819	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ASPM	Unknown	25991819	Open Targets	—
		ATM	Unknown	25991819	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP2B3	Unknown	33481259	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	25991819	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		B2M	Unknown	24970810	Open Targets	Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection +14 more
		BCL2	Unknown	33481259 25991819 24970810	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		BCL6	Unknown	33481259 25991819 24970810	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BCL7A	Unknown	25991819	Open Targets	ATP-dependent chromatin remodeling
		BCL9L	Unknown	24970810	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	24970810	Open Targets	—
		BCR	Unknown	25991819	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BMP5	Unknown	25991819 24970810	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BRAF	Unknown	25991819	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BTG1	Unknown	33481259 25991819 24970810	Open Targets	RNA degradation FOXO-mediated transcription of cell cycle genes
		BTG2	Unknown	33481259 25991819	Open Targets	RNA degradation TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		CARD11	Unknown	28619981 25991819 20544211 33481259 26111727 24970810	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CCND2	Unknown	33481259	Open Targets	FoxO signaling pathway Cell cycle p53 signaling pathway +18 more
		CCND3	Unknown	33481259 25991819	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CD79A	Unknown	25643939	Open Targets	B cell receptor signaling pathway Primary immunodeficiency CD22 mediated BCR regulation +1 more
		CD79B	Unknown	28619981 25991819 33481259 26111727 25643939 24970810 26195323	Open Targets	B cell receptor signaling pathway CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
		CDH10	Unknown	33481259	Open Targets	Adherens junctions interactions
		CDKN1B	Unknown	33481259 25991819	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	24970810 25991819 22837180 9546285	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHD4	Unknown	33481259 25991819	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CHST11	Unknown	24970810	Open Targets	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chondroitin sulfate biosynthesis
		CIITA	Unknown	25991819 24970810	Open Targets	Antigen processing and presentation Toxoplasmosis Tuberculosis +3 more
		CNBD1	Unknown	25991819	Open Targets	—
		CNOT3	Unknown	33481259	Open Targets	RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		CNTNAP2	Unknown	25991819 24970810	Open Targets	Cell adhesion molecules
		COL3A1	Unknown	33481259	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		CREB1	Unknown	33481259	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis +53 more
		CREBBP	Unknown	26111727	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CSMD3	Unknown	33481259 25991819 24970810	Open Targets	—
		CTNNA1	Unknown	25991819	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +9 more
		CTNNA2	Unknown	24970810	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNND2	Unknown	33481259	Open Targets	Wnt signaling pathway
		CXCR4	Unknown	24970810	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		DCC	Unknown	25991819 24970810	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DDX10	Unknown	25991819	Open Targets	—
		DDX5	Unknown	25991819	Open Targets	Spliceosome Transcriptional misregulation in cancer Proteoglycans in cancer +3 more

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Primary central nervous system lymphoma

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