Subtype of: Chondrosarcoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
primary central chondrosarcoma	EFO_0010832	ALK	Unknown	25024164	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ARHGEF12	Unknown	25024164	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		BCL11A	Unknown	23770606	Open Targets	—
		CDKN2A	Unknown	37019410 23146407	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CLP1	Unknown	23770606	Open Targets	mRNA surveillance pathway tRNA processing in the nucleus mRNA Splicing - Major Pathway +3 more
		CNTNAP2	Unknown	25024164	Open Targets	Cell adhesion molecules
		CNTRL	Unknown	23770606	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		COL2A1	Unknown	23770606 25024164	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +14 more
		CTNNA2	Unknown	23770606	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		DNMT3A	Unknown	23770606	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ELL	Unknown	23770606	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		EPHA3	Unknown	25024164	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	23770606	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		ERBB3	Unknown	23770606	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		EWSR1	Unknown	8570200 23154773	Open Targets	Transcriptional misregulation in cancer
		FBXO11	Unknown	23770606	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		HEY1	Unknown	22034177	Open Targets	Notch signaling pathway Human papillomavirus infection Pathways in cancer +4 more
		IDH1	Unknown	25432631 31297850 23770606 30296521 25024164 23958880 22928481 35765075 21598255 32742915	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	23770606 32742915 21598255 23958880	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKBKB	Unknown	23770606	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IRS4	Unknown	23770606	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ISX	Unknown	23770606	Open Targets	—
		KDR	Unknown	25024164	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		LRP1B	Unknown	23770606	Open Targets	—
		MEN1	Unknown	25024164	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MUC16	Unknown	23770606 25024164	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	25024164	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	25024164	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		NBEA	Unknown	23770606	Open Targets	—
		NCOA2	Unknown	22034177	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NR4A3	Unknown	8570200 23154773	Open Targets	Transcriptional misregulation in cancer Nuclear Receptor transcription pathway RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
		NRAS	Unknown	23714727	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		PDE4DIP	Unknown	23770606	Open Targets	—
		PLEC	Unknown	23770606	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PTCH1	Unknown	23770606	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTPRB	Unknown	25024164	Open Targets	Adherens junction Neutrophil degranulation
		RB1	Unknown	23146407	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RGS7	Unknown	23770606	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		SETD2	Unknown	23770606	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SMARCB1	Unknown	23154773	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SOX2	Unknown	37019410	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPECC1	Unknown	23770606	Open Targets	—
		SUFU	Unknown	23770606	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		TEC	Unknown	23770606	Open Targets	Osteoclast differentiation T cell receptor signaling pathway Signaling by SCF-KIT +2 more
		TET2	Unknown	23770606	Open Targets	—
		TP53	Unknown	23770606 25024164	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TRIP11	Unknown	23770606	Open Targets	Intraflagellar transport Intra-Golgi traffic
		ZFHX3	Unknown	25024164	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM3	Unknown	23770606	Open Targets	—
		ZNF479	Unknown	23770606	Open Targets	Generic Transcription Pathway

Primary central chondrosarcoma

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