Premature ovarian failure

Mismatch repair

Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +11 more

Mitochondrial translation elongation Mitochondrial translation termination

MAPK signaling pathway ErbB signaling pathway Cell cycle PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway TGF-beta signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway Thyroid hormone signaling pathway Salmonella infection Hepatitis C Hepatitis B Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Endometrial cancer Thyroid cancer Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Transcription of E2F targets under negative control by DREAM complex NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Binding of TCF/LEF:CTNNB1 to target gene promoters MAPK6/MAPK4 signaling Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry TFAP2 (AP-2) family regulates transcription of cell cycle factors RUNX3 regulates WNT signaling Estrogen-dependent gene expression +45 more

Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Lipid and atherosclerosis Fluid shear stress and atherosclerosis +4 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apelin signaling pathway Platelet activation Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling +24 more

Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Thyroid hormone signaling pathway Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Breast cancer Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription +13 more

Cortisol synthesis and secretion Cushing syndrome Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Transcriptional regulation of pluripotent stem cells +2 more

Maturity onset diabetes of the young Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Estrogen-dependent gene expression +1 more

MAPK signaling pathway Ras signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Apoptosis Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer Central carbon metabolism in cancer Frs2-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling TRKA activation by NGF PI3K/AKT activation +13 more

Chromatin modifying enzymes

Rap1 signaling pathway Chemokine signaling pathway Endocytosis Axon guidance Hippo signaling pathway Adherens junction Tight junction Human papillomavirus infection TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions +7 more

Fructose and mannose metabolism Amino sugar and nucleotide sugar metabolism Metabolic pathways Biosynthesis of cofactors Biosynthesis of nucleotide sugars Defective PMM2 causes PMM2-CDG (CDG-1a) Synthesis of GDP-mannose +4 more

Glycerophospholipid metabolism

Base excision repair

Cytochrome P450 - arranged by substrate type

DNA replication Inhibition of replication initiation of damaged DNA by RB1/E2F1 Polymerase switching on the C-strand of the telomere Telomere C-strand synthesis initiation DNA replication initiation Activation of the pre-replicative complex Polymerase switching Removal of the Flap Intermediate Processive synthesis on the lagging strand +6 more

Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species Sphingolipid de novo biosynthesis +1 more

Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling PI3K-Akt signaling pathway JAK-STAT signaling pathway Prolactin signaling pathway Prolactin receptor signaling Growth hormone receptor signaling +5 more

Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production +4 more

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production +5 more

Homologous recombination

Oocyte meiosis

mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation +3 more

Insulin secretion

Calcium signaling pathway Apelin signaling pathway Circadian entrainment Oxytocin signaling pathway Salivary secretion Alzheimer disease Parkinson disease Prion disease Pathways of neurodegeneration - multiple diseases Stimuli-sensing channels Ion homeostasis +8 more

Virion - Hepatitis viruses Phagosome Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Fat digestion and absorption Bile secretion Vitamin digestion and absorption Cholesterol metabolism Hepatitis C Scavenging by Class B Receptors HDL clearance +10 more

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +3 more

Neurotrophin signaling pathway Prolactin receptor signaling Growth hormone receptor signaling Factors involved in megakaryocyte development and platelet production +1 more

Nicotinate and nicotinamide metabolism Metabolic pathways Thermogenesis Central carbon metabolism in cancer Processing of DNA double-strand break ends +2 more

Oocyte meiosis

Rap1 signaling pathway p53 signaling pathway Phagosome Efferocytosis PI3K-Akt signaling pathway TGF-beta signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Malaria Human papillomavirus infection Proteoglycans in cancer MicroRNAs in cancer Bladder cancer Platelet degranulation Signaling by PDGF Integrin cell surface interactions Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +17 more

MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors +5 more

Tight junction

Transcriptional misregulation in cancer

Protein digestion and absorption Post-translational modification: synthesis of GPI-anchored proteins

Nucleocytoplasmic transport MicroRNA (miRNA) biogenesis

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Non-integrin membrane-ECM interactions Collagen chain trimerization +18 more

Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange +3 more

Tyrosine metabolism Metabolic pathways Citric acid cycle (TCA cycle)