Pena-shokeir syndrome

Motor proteins Cytoskeleton in muscle cells Striated Muscle Contraction

Purine metabolism Alanine, aspartate and glutamate metabolism Metabolic pathways Nucleotide metabolism Biosynthesis of cofactors Purine ribonucleoside monophosphate biosynthesis +3 more

Alanine, aspartate and glutamate metabolism Butanoate metabolism Metabolic pathways Degradation of GABA +1 more

Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway Lysosome Glycosphingolipid metabolism Neutrophil degranulation +3 more

ALKBH3 mediated reversal of alkylation damage

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Adrenergic signaling in cardiomyocytes Aldosterone synthesis and secretion Endocrine and other factor-regulated calcium reabsorption Salivary secretion Pancreatic secretion Mineral absorption Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +9 more

Formation of apoptosome Regulation of the apoptosome activity

Neuroactive ligand-receptor interaction Highly sodium permeable postsynaptic acetylcholine nicotinic receptors

Neuroactive ligand-receptor interaction Highly sodium permeable postsynaptic acetylcholine nicotinic receptors

Cell adhesion molecules

Phagosome Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation +21 more

Porphyrin metabolism Aminoacyl-tRNA biosynthesis Metabolic pathways Biosynthesis of cofactors +1 more

RNA degradation ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol +4 more

Cytoskeleton in muscle cells Molecules associated with elastic fibres

Cytoskeleton in muscle cells Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres +1 more

Starch and sucrose metabolism Metabolic pathways Glycogen synthesis Glycogen storage disease type IV (GBE1) +1 more

RAF/MAP kinase cascade RET signaling

Endocytosis

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

LGI-ADAM interactions

Rap1 signaling pathway

Spinocerebellar ataxia Myogenesis

Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways Lysosome

Stimuli-sensing channels

Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events +25 more

Wnt signaling pathway Asymmetric localization of PCP proteins

Wnt signaling pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2

Calcium signaling pathway Apelin signaling pathway Circadian entrainment Long-term depression Oxytocin signaling pathway Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Stimuli-sensing channels Ion homeostasis +7 more

Calcium signaling pathway Apelin signaling pathway Circadian entrainment Oxytocin signaling pathway Salivary secretion Alzheimer disease Parkinson disease Prion disease Pathways of neurodegeneration - multiple diseases Stimuli-sensing channels Ion homeostasis +8 more

Phase 0 - rapid depolarisation

Adrenergic signaling in cardiomyocytes Phase 0 - rapid depolarisation

Phase 0 - rapid depolarisation

Synaptic vesicle cycle Cholinergic synapse Acetylcholine Neurotransmitter Release Cycle Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +2 more

Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerisation of the Nuclear Lamina

Phagosome Apoptosis Tight junction Gap junction Motor proteins Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Anchoring of the basal body to the plasma membrane Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Carboxyterminal post-translational modifications of tubulin HCMV Early Events Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins +39 more