Subtype of: Ovarian cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ovarian clear cell adenocarcinoma	MONDO_0006045	MAML2	Unknown	33947352	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MAP3K1	Unknown	28481359 29986747	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MET	Unknown	33947352	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MITF	Unknown	33947352	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLH1	Unknown	30851247 26920370 33947352	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MSH2	Unknown	33153119 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	26920370 23791828	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MYB	Unknown	33947352	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		MYC	Unknown	33947352	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYH11	Unknown	33947352 20826764	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		MYH9	Unknown	33947352	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		NCOA2	Unknown	33947352	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NF1	Unknown	26920370 33947352	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	33947352	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFE2L2	Unknown	27939411 33947352	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NFKB2	Unknown	33947352	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NIN	Unknown	33947352	Open Targets	—
		NOTCH1	Unknown	26920370	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	26920370 28481359 29986747 33153119	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	28481359	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NR2F2	Unknown	20826764	Open Targets	—
		NRAS	Unknown	24889043	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NSD1	Unknown	33947352	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK3	Unknown	33947352	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		NUMA1	Unknown	33947352	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP98	Unknown	33947352 20826764	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PAX3	Unknown	33947352	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PBRM1	Unknown	26920370 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PDE4DIP	Unknown	20826764	Open Targets	—
		PDGFB	Unknown	33947352	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PDGFRA	Unknown	26920370	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	33947352	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PER1	Unknown	33947352	Open Targets	Circadian rhythm Circadian entrainment
		PIK3CA	Unknown	28734796 23430509 23716351 15712344 24336158 15520168 25846456 32616873 19029838 24927217 22696596 23791828 24523919 27588476 29654067 24557434 33947352 21735444 22271473 22705003 20826764 27939411 29986747 36729997 31538426 25245602 20942669 26276776 33153119 23267135 22157930 22955107 24299208 30851247 19349352 17258789 22487539 36531003 26920370 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	26920370	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	28481359 33947352	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLCG1	Unknown	26920370	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PML	Unknown	33947352	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS2	Unknown	33947352	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLE	Unknown	28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPARG	Unknown	33947352	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPP2R1A	Unknown	23267135 27939411 21381030 33947352 20826764 21882256 26920370 28481359 21435433	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PRDM1	Unknown	26920370 33947352	Open Targets	Regulation of TP53 Expression
		PSIP1	Unknown	33947352	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	27939411 33947352	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	27939411 24240112 31472684 15668893 31538426 19349352 33153119 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRD	Unknown	28481359 33947352	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRT	Unknown	26920370 28481359 33947352	Open Targets	—
		RAD50	Unknown	33947352 36729997	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more

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Ovarian clear cell adenocarcinoma

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