Orofacial cleft

Regulation of actin cytoskeleton

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis +2 more

MicroRNAs in cancer Formation of the cornified envelope

tRNA modification in the nucleus and cytosol

Cytokine-cytokine receptor interaction PPARA activates gene expression

MET interacts with TNS proteins

MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors +5 more

NGF-stimulated transcription

Antigen processing: Ubiquitination & Proteasome degradation

Shigellosis

Antigen processing: Ubiquitination & Proteasome degradation

Major pathway of rRNA processing in the nucleolus and cytosol

mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Melanogenesis Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer WNT ligand biogenesis and trafficking +13 more

Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Adherens junctions interactions

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Protein digestion and absorption Human papillomavirus infection Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization +14 more

Virion - Herpesvirus Cell adhesion molecules Adherens junction Herpes simplex virus 1 infection Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adherens junctions interactions Nectin/Necl trans heterodimerization +4 more

Cell cycle Cohesin Loading onto Chromatin

Cell adhesion molecules Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Nectin/Necl trans heterodimerization

Parathyroid hormone synthesis, secretion and action Transcriptional misregulation in cancer Transcriptional regulation by RUNX2 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Regulation of RUNX2 expression and activity RUNX2 regulates osteoblast differentiation RUNX2 regulates bone development RUNX2 regulates genes involved in cell migration RUNX2 regulates genes involved in differentiation of myeloid cells +6 more

Wnt signaling pathway Axon guidance TCF dependent signaling in response to WNT

B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination +1 more

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy Platelet degranulation Striated Muscle Contraction +2 more

Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer Interleukin-4 and Interleukin-13 signaling +1 more

Nucleocytoplasmic transport Fluid shear stress and atherosclerosis SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint Regulation of IFNG signaling Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation +22 more

Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway Cell adhesion molecules Adherens junction Bacterial invasion of epithelial cells Pathways in cancer Endometrial cancer Thyroid cancer Melanoma Bladder cancer Gastric cancer Degradation of the extracellular matrix Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells +15 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Protein digestion and absorption Human papillomavirus infection Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization +14 more

Hippo signaling pathway Tight junction T cell receptor signaling pathway Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules +8 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Adherens junction Signaling pathways regulating pluripotency of stem cells Thermogenesis Regulation of actin cytoskeleton Parathyroid hormone synthesis, secretion and action Pathways in cancer Proteoglycans in cancer Prostate cancer Melanoma Breast cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling Signaling by FGFR1 amplification mutants Signaling by activated point mutants of FGFR1 FGFR1b ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Phospholipase C-mediated cascade: FGFR1 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling Negative regulation of FGFR1 signaling Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by plasma membrane FGFR1 fusions +32 more

Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Pathways in cancer Breast cancer Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH3 Activation and Transmission of Signal to the Nucleus +8 more

Parathyroid hormone synthesis, secretion and action Activation of Matrix Metalloproteinases Neutrophil degranulation

IL-17 signaling pathway TNF signaling pathway Coronavirus disease - COVID-19 Transcriptional misregulation in cancer Prostate cancer Rheumatoid arthritis Lipid and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EGFR Transactivation by Gastrin Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling +11 more

Endocrine resistance IL-17 signaling pathway TNF signaling pathway Leukocyte transendothelial migration Estrogen signaling pathway Relaxin signaling pathway Hepatitis B Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Bladder cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Signaling by SCF-KIT Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling +22 more

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

Th17 cell differentiation Estrogen signaling pathway Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Signaling by Retinoic Acid Transcriptional regulation of granulopoiesis +6 more