Optic atrophy

Peroxisome Peroxisomal protein import Class I peroxisomal membrane protein import

Glycolysis / Gluconeogenesis Metabolic pathways Carbon metabolism Biosynthesis of amino acids HIF-1 signaling pathway Glycolysis Gluconeogenesis Manipulation of host energy metabolism +5 more

Peroxisome Alpha-oxidation of phytanate Peroxisomal protein import

FoxO signaling pathway Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +5 more

Processing of SMDT1

Glycerophospholipid metabolism Glycerophospholipid catabolism

RNA polymerase Cytosolic DNA-sensing pathway Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter +3 more

Mannose type O-glycan biosynthesis Metabolic pathways Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 O-linked glycosylation +1 more

Transcriptional misregulation in cancer

Efferocytosis Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Complement cascade +7 more

Endocrine resistance Cell cycle Cellular senescence Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Pancreatic cancer Glioma Prostate cancer Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Condensation of Prophase Chromosomes Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry +30 more

The retinoid cycle in cones (daylight vision) The canonical retinoid cycle in rods (twilight vision)

Retinol metabolism Metabolic pathways Biosynthesis of cofactors The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway Retinoid metabolism and transport +3 more

Retinol metabolism Metabolic pathways Biosynthesis of cofactors Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) +2 more

Retinol metabolism Metabolic pathways Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway +2 more

Olfactory Signaling Pathway

G alpha (i) signalling events Opsins

Phototransduction Cocaine addiction Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding +2 more

Phototransduction The canonical retinoid cycle in rods (twilight vision) Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade G alpha (i) signalling events Opsins VxPx cargo-targeting to cilium +4 more

The retinoid cycle in cones (daylight vision) Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision)

Spliceosome

Hedgehog 'off' state Anchoring of the basal body to the plasma membrane

Anchoring of the basal body to the plasma membrane

Axon guidance Other semaphorin interactions

Axon guidance

Platelet degranulation

Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs

Phototransduction Sodium/Calcium exchangers Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D)

Synaptic vesicle cycle Insulin secretion Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Other interleukin signaling Toxicity of botulinum toxin type A (BoNT/A) Toxicity of botulinum toxin type C (BoNT/C) Toxicity of botulinum toxin type E (BoNT/E) Neutrophil degranulation GABA synthesis, release, reuptake and degradation +10 more

DNA replication Mismatch repair Homologous recombination Transcriptional activation of mitochondrial biogenesis +1 more

Influenza A Coronavirus disease - COVID-19 Transcriptional misregulation in cancer Prostate cancer +1 more

SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of immune response proteins

tRNA processing in the nucleus tRNA processing in the mitochondrion

TRP channels

RNA polymerase Cytosolic DNA-sensing pathway Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter +3 more