Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
open-angle glaucoma	EFO_0004190 MONDO:0005338	MYOC	Causal	10815160 11004290 11774072 16862071 19148291 21821918 23517641 26396484 27080696 32300215 33627673 36777996 38382466 39024449 9005853 9328473 9490287 9501861 9521427 9556305 9639450 9772276 9832047 9863594	ClinGen, GWAS catalog	—
		ABCA1	Unknown	25173105 25173107 29452408 29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	ABC transporters Efferocytosis Fat digestion and absorption +6 more
		ABI3BP	Unknown	37386247	GWAS catalog	—
		ABITRAM	Unknown	37386247	GWAS catalog	—
		ABLIM3	Unknown	37386247	GWAS catalog	Axon guidance
		ABO	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +1 more
		ABRA	Unknown	37386247	GWAS catalog	—
		ABRAXAS2	Unknown	37386247	GWAS catalog	Metalloprotease DUBs
		ACOXL	Unknown	29891935 37386247 39024449	GWAS catalog	Beta-oxidation of pristanoyl-CoA
		ADAM15	Unknown	37386247	GWAS catalog	Degradation of the extracellular matrix Invadopodia formation
		ADAMTS15	Unknown	37386247	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS19	Unknown	39024449	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS6	Unknown	37386247	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS8	Unknown	33627673 37386247 39024449	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTSL2	Unknown	37386247	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADGRB2	Unknown	37386247	GWAS catalog	—
		ADGRL3	Unknown	37386247 38382466	GWAS catalog	—
		AFAP1	Unknown	25173105 25861811 27623284 29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	—
		AGBL2	Unknown	33627673 37386247 39024449	GWAS catalog	—
		AJUBA	Unknown	39024449	GWAS catalog	Hippo signaling pathway Hippo signaling pathway - multiple species Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha +1 more
		AKR1A1	Unknown	37386247	GWAS catalog	Glycolysis / Gluconeogenesis Pentose and glucuronate interconversions Ascorbate and aldarate metabolism +7 more
		ALCAM	Unknown	33627673 37386247	GWAS catalog	Cell adhesion molecules
		ALDH9A1	Unknown	25173105	GWAS catalog	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +11 more
		ALX3	Unknown	37386247	GWAS catalog	—
		ANAPC1	Unknown	37386247	GWAS catalog	Cell cycle Oocyte meiosis Ubiquitin mediated proteolysis +18 more
		ANGPT1	Unknown	29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +5 more
		ANGPT2	Unknown	37386247	GWAS catalog	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +4 more
		ANGPTL2	Unknown	37386247	GWAS catalog	—
		ANGPTL7	Unknown	36777996	GWAS catalog	—
		ANKH	Unknown	29891935 33627673 37386247 38382466 39024449	GWAS catalog	Miscellaneous transport and binding events
		ANTXR1	Unknown	33627673 37386247 38382466	GWAS catalog	NOD-like receptor signaling pathway Uptake and function of anthrax toxins
		ANXA11	Unknown	37386247	GWAS catalog	Amyotrophic lateral sclerosis
		APBB2	Unknown	31688885	GWAS catalog	—
		APP	Unknown	33627673 37386247 38382466	GWAS catalog	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		AREL1	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		ARHGAP1	Unknown	37386247	GWAS catalog	Rho GTPase cycle
		ARHGAP20	Unknown	37386247 39024449	GWAS catalog	Rho GTPase cycle
		ARHGAP21	Unknown	37386247	GWAS catalog	Rho GTPase cycle
		ARHGEF12	Unknown	25173105 29891935 33627673 36777996 37386247 38382466 39024449	GWAS catalog	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARHGEF3	Unknown	33627673 37386247	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ASB7	Unknown	37386247 39024449	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		ATOH7	Unknown	39024449	GWAS catalog	—
		ATXN2	Unknown	26752265 33627673 37386247 38382466	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		BABAM2	Unknown	37386247	GWAS catalog	Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +3 more
		BBS9	Unknown	37386247	GWAS catalog	BBSome-mediated cargo-targeting to cilium
		BCAR1	Unknown	37386247	GWAS catalog	Rap1 signaling pathway Chemokine signaling pathway Efferocytosis +12 more
		BCAR3	Unknown	37386247	GWAS catalog	—
		BCAS3	Unknown	36777996 37386247 38382466	GWAS catalog	—
		BICC1	Unknown	29891935 33627673 36777996 37386247 38382466	GWAS catalog	—
		LTBP2	Unknown	33627673 36777996 37386247 38382466 39024449	GWAS catalog	Molecules associated with elastic fibres
PRIMARY OPEN ANGLE GLAUCOMA	C0339573	LTBP2	Causal	—	Disgenet	Molecules associated with elastic fibres
PRIMARY OPEN ANGLE GLAUCOMA	C0339573	MYOC	Causal	—	Disgenet	—

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Open angle glaucoma

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