Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
non-functional pancreatic neuroendocrine tumor	MONDO_0004334	ABI1	Unknown	29486199	Open Targets	Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation +3 more
		AKT1	Unknown	27994516	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ARID1A	Unknown	29486199 27994516 31819132	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	29486199	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ATIC	Unknown	33747156	Open Targets	Purine metabolism One carbon pool by folate Metabolic pathways +2 more
		ATM	Unknown	27994516	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATRX	Unknown	29486199 27994516 31819132 33747156	Open Targets	Cell cycle
		BCL9	Unknown	29486199	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCLAF1	Unknown	29486199	Open Targets	—
		BCOR	Unknown	31819132	Open Targets	Polycomb repressive complex
		BIRC6	Unknown	33747156	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		CALR	Unknown	29486199	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CBLC	Unknown	29486199	Open Targets	Ubiquitin mediated proteolysis Endocytosis
		CCND1	Unknown	27994516	Open Targets	Endocrine resistance FoxO signaling pathway Cell cycle +58 more
		CCND3	Unknown	27994516	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CDKN1B	Unknown	29486199 27994516	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	25003221 9443399	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CLTCL1	Unknown	29486199	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +8 more
		CREBBP	Unknown	29486199	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		DAXX	Unknown	29486199 27994516 31819132	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DDR2	Unknown	33747156	Open Targets	Non-integrin membrane-ECM interactions
		DNMT3A	Unknown	33747156	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ERBB4	Unknown	29486199 33747156	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	29486199	Open Targets	NF-kappa B signaling pathway
		FAS	Unknown	29486199	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT3	Unknown	29486199	Open Targets	—
		FGFR2	Unknown	33747156	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR3	Unknown	33747156	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		HIF1A	Unknown	27994516	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HLA-A	Unknown	29486199	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		IRS4	Unknown	29486199	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		ISX	Unknown	29486199	Open Targets	—
		ITGAV	Unknown	33747156	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		JAK3	Unknown	33747156	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KAT7	Unknown	29486199	Open Targets	HATs acetylate histones
		KIT	Unknown	27994516	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	29486199	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	9875139	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		MDM4	Unknown	29486199	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MEN1	Unknown	29486199 33747156 10594843 31819132 9458074 27994516 9766672	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MGMT	Unknown	27994516	Open Targets	MGMT-mediated DNA damage reversal
		MLH1	Unknown	33747156	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MTOR	Unknown	27994516	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	29486199	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	29486199	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	29486199	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUTYH	Unknown	29486199	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine +2 more
		MYH9	Unknown	29486199	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		NCOR2	Unknown	29486199	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NF1	Unknown	27994516	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more

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Non-functional pancreatic neuroendocrine tumor

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