Neural tube defect

Antigen processing: Ubiquitination & Proteasome degradation

Glycine, serine and threonine metabolism Cysteine and methionine metabolism One carbon pool by folate Metabolic pathways Folate transport and metabolism Sulfur amino acid metabolism Choline catabolism +4 more

Glycine, serine and threonine metabolism Cysteine and methionine metabolism One carbon pool by folate Metabolic pathways Biosynthesis of amino acids Cysteine formation from homocysteine +3 more

ATP-dependent chromatin remodeling

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Shigellosis Amoebiasis Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 Transcriptional misregulation in cancer Acute myeloid leukemia Rheumatoid arthritis Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling +18 more

Steroid hormone biosynthesis Caffeine metabolism Tryptophan metabolism Linoleic acid metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs +15 more

Antifolate resistance Endocytosis Folate transport and metabolism COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport +3 more

Antifolate resistance Endocytosis Folate transport and metabolism Post-translational modification: synthesis of GPI-anchored proteins Metabolism of folate and pterines +2 more

Hedgehog 'off' state

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action G alpha (q) signalling events Synthesis, secretion, and deacylation of Ghrelin +3 more

cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription +5 more

Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Type I diabetes mellitus Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Influenza A Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Fluid shear stress and atherosclerosis Interferon gamma signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +33 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Regulation of actin cytoskeleton Insulin signaling pathway Insulin secretion Ovarian steroidogenesis Progesterone-mediated oocyte maturation Prolactin signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Type I diabetes mellitus Maturity onset diabetes of the young Aldosterone-regulated sodium reabsorption Alzheimer disease Prostate cancer Diabetic cardiomyopathy Insulin processing Synthesis, secretion, and deacylation of Ghrelin COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation +39 more

One carbon pool by folate Metabolic pathways Biosynthesis of cofactors Folate transport and metabolism Metabolism of folate and pterines +2 more

One carbon pool by folate Metabolic pathways Biosynthesis of cofactors Metabolism of folate and pterines +1 more

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

Cysteine and methionine metabolism Selenocompound metabolism One carbon pool by folate Metabolic pathways Biosynthesis of amino acids Cobalamin transport and metabolism Folate transport and metabolism Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG +9 more

Cobalamin transport and metabolism Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG +3 more

Caffeine metabolism Drug metabolism - other enzymes Metabolic pathways Chemical carcinogenesis - DNA adducts Acetylation +2 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes Peptide ligand-binding receptors G alpha (i) signalling events +2 more

Transcriptional misregulation in cancer HATs acetylate histones

Formation of the cornified envelope

Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (i) signalling events

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Interconversion of nucleotide di- and triphosphates +4 more

TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity

MET Receptor Activation Signaling by MST1

Chemical carcinogenesis - DNA adducts Cytosolic sulfonation of small molecules

Wnt signaling pathway

Wnt signaling pathway

Mitophagy - animal Autophagy - animal Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Macroautophagy +5 more

Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Legionellosis Tuberculosis Hepatitis C Hepatitis B Measles Influenza A Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Small cell lung cancer Lipid and atherosclerosis Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage Neutrophil degranulation TP53 Regulates Transcription of Caspase Activators and Caspases Transcriptional Regulation by E2F6 Regulation of the apoptosome activity +24 more

Lysosome Glycosphingolipid metabolism The activation of arylsulfatases

Glycine, serine and threonine metabolism Cysteine and methionine metabolism One carbon pool by folate Metabolic pathways Folate transport and metabolism Sulfur amino acid metabolism Choline catabolism +4 more

ATP-dependent chromatin remodeling

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Shigellosis Amoebiasis Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 Transcriptional misregulation in cancer Acute myeloid leukemia Rheumatoid arthritis Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin-10 signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells Interleukin receptor SHC signaling +18 more

Steroid hormone biosynthesis Caffeine metabolism Tryptophan metabolism Linoleic acid metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs +15 more

Rho GTPase cycle

Antifolate resistance Endocytosis Folate transport and metabolism COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport +3 more

Antifolate resistance Endocytosis Folate transport and metabolism Post-translational modification: synthesis of GPI-anchored proteins Metabolism of folate and pterines +2 more

Hedgehog 'off' state

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action G alpha (q) signalling events Synthesis, secretion, and deacylation of Ghrelin +3 more

cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state GLI proteins bind promoters of Hh responsive genes to promote transcription +5 more

Antigen processing: Ubiquitination & Proteasome degradation

Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Type I diabetes mellitus Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Influenza A Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Fluid shear stress and atherosclerosis Interferon gamma signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +33 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Regulation of actin cytoskeleton Insulin signaling pathway Insulin secretion Ovarian steroidogenesis Progesterone-mediated oocyte maturation Prolactin signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Type I diabetes mellitus Maturity onset diabetes of the young Aldosterone-regulated sodium reabsorption Alzheimer disease Prostate cancer Diabetic cardiomyopathy Insulin processing Synthesis, secretion, and deacylation of Ghrelin COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation +39 more

Virion - Rotavirus Rap1 signaling pathway Phagosome PI3K-Akt signaling pathway Axon guidance Focal adhesion ECM-receptor interaction Cell adhesion molecules Tight junction Platelet activation Leukocyte transendothelial migration Regulation of actin cytoskeleton Cytoskeleton in muscle cells Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Pertussis Yersinia infection Leishmaniasis Toxoplasmosis Human papillomavirus infection Pathways in cancer Proteoglycans in cancer Small cell lung cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Laminin interactions Syndecan interactions ECM proteoglycans Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling MET activates PTK2 signaling MET interacts with TNS proteins HCMV Early Events +41 more

Lysine degradation Metabolic pathways PKMTs methylate histone lysines

One carbon pool by folate Metabolic pathways Biosynthesis of cofactors Folate transport and metabolism Metabolism of folate and pterines +2 more

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

Caffeine metabolism Drug metabolism - other enzymes Metabolic pathways Chemical carcinogenesis - DNA adducts Acetylation +2 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes Peptide ligand-binding receptors G alpha (i) signalling events +2 more

Rap1 signaling pathway Chemokine signaling pathway Endocytosis Axon guidance Hippo signaling pathway Adherens junction Tight junction Human papillomavirus infection TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions +7 more

Transcriptional misregulation in cancer HATs acetylate histones

Insulin signaling pathway PKA activation PKA activation in glucagon signalling DARPP-32 events Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production +7 more

Formation of the cornified envelope

Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (i) signalling events

Cellular senescence Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +4 more

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Interconversion of nucleotide di- and triphosphates +4 more

Hippo signaling pathway Tight junction Human papillomavirus infection Viral carcinogenesis +1 more

TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity

MET Receptor Activation Signaling by MST1

Chemical carcinogenesis - DNA adducts Cytosolic sulfonation of small molecules

Wnt signaling pathway

Wnt signaling pathway

Autophagy - other Autophagy - animal Alzheimer disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Shigellosis Macroautophagy XBP1(S) activates chaperone genes +7 more