Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
nasal cavity and paranasal sinus carcinoma	MONDO_0056819	ACVR1	Unknown	28493366	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		AMER1	Unknown	28493366	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		APC	Unknown	33500480 28493366 38362701 16906516	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	38362701 28493366	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARID1A	Unknown	28084339 28481359 28493366	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	28084339 38085333	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	28493366	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASXL1	Unknown	28084339	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	38362701 33500480	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATR	Unknown	28493366	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		ATRX	Unknown	28481359 28493366	Open Targets	Cell cycle
		AXIN1	Unknown	28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		BARD1	Unknown	28481359	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BCOR	Unknown	28493366	Open Targets	Polycomb repressive complex
		BRAF	Unknown	33500480 23791006 24338245 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	33500480	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	33500480 38362701 28493366	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CDKN1B	Unknown	33500480 28493366	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	33500480 28493366	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CREBBP	Unknown	28084339 28493366	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CTCF	Unknown	28481359	Open Targets	—
		CTNNB1	Unknown	30302299 33500480 28493366	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DDR2	Unknown	33500480	Open Targets	Non-integrin membrane-ECM interactions
		EGFR	Unknown	23791006 24338245	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EPHA7	Unknown	28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		ERBB2	Unknown	33500480 28084339 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	38362701 33500480	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	33500480	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ESR1	Unknown	33500480 38085333	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		FBXO11	Unknown	28084339	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	28493366	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR3	Unknown	28493366	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FLT3	Unknown	28493366	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	28493366	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FOXA1	Unknown	33500480	Open Targets	Estrogen-dependent gene expression
		FOXL2	Unknown	33500480	Open Targets	SUMOylation of transcription factors
		GATA1	Unknown	28493366	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		GNA11	Unknown	28493366	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway Hormone signaling +23 more
		HRAS	Unknown	10421261	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH1	Unknown	31876581 33500480	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	34265800 31876581 28493366	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		JAK3	Unknown	33500480	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KDM6A	Unknown	28493366	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KEAP1	Unknown	28493366	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KMT2A	Unknown	33500480	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	38362701 28493366	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	29879069 33500480 10421261 27258560 23791006 30602616 18289366 15492756 24338245 38362701 16906516 9563649 28493366	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LRP1B	Unknown	38362701 33500480	Open Targets	—
		MAP2K1	Unknown	38362701 33500480	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more

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Nasal cavity and paranasal sinus carcinoma

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