Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ACUTE MYELOID LEUKEMIA	MONDO:0018874	ANKRD26	Unknown	—	GenCC	—
		CBFB	Unknown	12434152 15566413 17022082	GWAS catalog	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CHEK2	Unknown	—	GenCC	Cell cycle p53 signaling pathway Cellular senescence +9 more
		SRP72	Unknown	—	GenCC	Protein export SRP-dependent cotranslational protein targeting to membrane
ATYPICAL CHRONIC MYELOID LEUKEMIA	98824	CSF3R	Unknown	23656643	Orphanet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
CHRONIC MYELOID LEUKEMIA	521	ABL1	Unknown	—	Orphanet	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		BCR	Unknown	—	Orphanet	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		RUNX1	Unknown	22318203	Orphanet	Tight junction Th17 cell differentiation Pathways in cancer +20 more
LEUKEMIA, ACUTE MYELOID	601626	CEBPA	Unknown	—	HPO	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		DNMT3A	Unknown	—	HPO	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ETV6	Unknown	—	HPO	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		FLT3	Unknown	—	HPO	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		JAK2	Unknown	—	HPO	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		KIT	Unknown	—	HPO	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KRAS	Unknown	—	HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LPP	Unknown	—	HPO	—
		MLLT10	Unknown	—	HPO	—
		NPM1	Unknown	—	HPO	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NUP214	Unknown	—	HPO	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		PICALM	Unknown	—	HPO	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		RUNX1	Unknown	—	HPO	Tight junction Th17 cell differentiation Pathways in cancer +20 more
		SH3GL1	Unknown	—	HPO	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
LEUKEMIA, CHRONIC MYELOID	608232	ABL1	Unknown	—	HPO	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
LEUKEMIA, CHRONIC MYELOID	608232	BCR	Unknown	—	HPO	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
LEUKEMIA, MYELOID	MESH:D007951	AGO2	Unknown	21535412	CTD	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway +11 more
		ATG2B	Unknown	26280900	CTD	Autophagy - other Autophagy - animal Alzheimer disease +4 more
		CDO1	Unknown	40369079	CTD	Cysteine and methionine metabolism Taurine and hypotaurine metabolism Metabolic pathways +1 more
		GSKIP	Unknown	26280900	CTD	—
		HDAC2	Unknown	21535412	CTD	ATP-dependent chromatin remodeling Polycomb repressive complex Cell cycle +26 more
		KMT2A	Unknown	17463288 8282816	CTD	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2E	Unknown	18854576	CTD	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		MECOM	Unknown	23770046	CTD	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		NQO1	Unknown	11882782	CTD	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Biosynthesis of cofactors +5 more
		PRDX2	Unknown	16932348	CTD	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes
		RAD21	Unknown	23955599	CTD	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		SETBP1	Unknown	23832012	CTD	—
		SMARCD2	Unknown	28369036	CTD	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMC1A	Unknown	23955599	CTD	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SMC3	Unknown	23955599	CTD	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SPI1	Unknown	17361223	CTD	Osteoclast differentiation Human T-cell leukemia virus 1 infection Pathways in cancer +3 more
		STAG2	Unknown	23955599	CTD	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		TOP2B	Unknown	16932348	CTD	Platinum drug resistance SUMOylation of DNA replication proteins
		VEGFA	Unknown	21535412	CTD	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
LEUKEMIA, MYELOID, ACCELERATED PHASE	MESH:D015465	BMI1	Unknown	24571310	CTD	Polycomb repressive complex Signaling pathways regulating pluripotency of stem cells Transcriptional misregulation in cancer +9 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	ADCY7	Unknown	18206229	CTD	Purine metabolism Metabolic pathways Endocrine resistance +58 more
		AGRN	Unknown	17330099	CTD	ECM-receptor interaction Cytoskeleton in muscle cells A tetrasaccharide linker sequence is required for GAG synthesis +9 more
		ANXA2	Unknown	17330099	CTD	Salmonella infection Neutrophil degranulation Dissolution of Fibrin Clot +1 more
		ANXA4	Unknown	17330099	CTD	—
		ANXA5	Unknown	17330099	CTD	Platelet degranulation
		ANXA6	Unknown	17330099	CTD	—
		AQP9	Unknown	16968895	CTD	Neutrophil extracellular trap formation Bile secretion Transport of glycerol from adipocytes to the liver by Aquaporins +1 more
		ASMTL	Unknown	17330099	CTD	Pyrimidine metabolism Metabolic pathways Nucleotide metabolism
		ASXL2	Unknown	27798625	CTD	Polycomb repressive complex UCH proteinases
		CBFB	Unknown	18206229 27798625	CTD	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
		CEBPA	Unknown	18987666 19822134 30420649	CTD	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
		DNMT3A	Unknown	27335278	CTD	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ETV6	Unknown	—	CTD	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		FLT3	Unknown	17050201 17184839 19822134 21441929 21482694 21928377 22409268 23036488 23906301 24526162 25053825 27099147 27992414	CTD	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		JAK2	Unknown	16247455	CTD	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		KIT	Unknown	—	CTD	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	10339604 26237430	CTD	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	—	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LPP	Unknown	—	CTD	—
		MECOM	Unknown	30472098	CTD	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MLLT10	Unknown	—	CTD	—
		NPM1	Unknown	19822134 21441929 23877794 27992414 30420649	CTD	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NUP214	Unknown	—	CTD	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		PICALM	Unknown	—	CTD	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
		RUNX1	Unknown	18206229 27798625 30420649	CTD	Tight junction Th17 cell differentiation Pathways in cancer +20 more
		SH3GL1	Unknown	—	CTD	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SPI1	Unknown	26237430	CTD	Osteoclast differentiation Human T-cell leukemia virus 1 infection Pathways in cancer +3 more
LEUKEMIA, MYELOID, CHRONIC, ATYPICAL, BCR-ABL NEGATIVE	MESH:D054438	SETBP1	Unknown	23222956	CTD	—

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Myeloid leukemia

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