Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ACUTE MYELOID LEUKEMIA	MONDO:0018874	CEBPA	Causal	15575056 12661007 11242107	GWAS catalog	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
ACUTE MYELOID LEUKEMIA	MONDO:0018874	ETV6	Causal	—	GenCC	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
ACUTE MYELOID LEUKEMIA	MONDO:0018874	GATA2	Causal	—	GenCC	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
ACUTE MYELOID LEUKEMIA	MONDO:0018874	RTEL1	Causal	—	GenCC	Telomere Extension By Telomerase Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)
ACUTE MYELOID LEUKEMIA	MONDO:0018874	RUNX1	Causal	—	GenCC	Tight junction Th17 cell differentiation Pathways in cancer +20 more
ACUTE MYELOID LEUKEMIA	MONDO:0018874	TERT	Causal	—	GenCC	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
ACUTE MYELOID LEUKEMIA	MONDO:0018874	ANKRD26	Unknown	—	GenCC	—
ACUTE MYELOID LEUKEMIA	MONDO:0018874	CBFB	Unknown	12434152 15566413 17022082	GWAS catalog	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
ACUTE MYELOID LEUKEMIA	MONDO:0018874	CHEK2	Unknown	—	GenCC	Cell cycle p53 signaling pathway Cellular senescence +9 more
ACUTE MYELOID LEUKEMIA	MONDO:0018874	SRP72	Unknown	—	GenCC	Protein export SRP-dependent cotranslational protein targeting to membrane
ATYPICAL CHRONIC MYELOID LEUKEMIA	98824	CSF3R	Unknown	23656643	Orphanet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
CHRONIC MYELOID LEUKEMIA	521	ABL1	Unknown	—	Orphanet	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
CHRONIC MYELOID LEUKEMIA	521	BCR	Unknown	—	Orphanet	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
CHRONIC MYELOID LEUKEMIA	521	RUNX1	Unknown	22318203	Orphanet	Tight junction Th17 cell differentiation Pathways in cancer +20 more
LEUKEMIA, ACUTE MYELOID	601626	CEBPA	Unknown	—	HPO	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
LEUKEMIA, ACUTE MYELOID	601626	DNMT3A	Unknown	—	HPO	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
LEUKEMIA, ACUTE MYELOID	601626	ETV6	Unknown	—	HPO	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
LEUKEMIA, ACUTE MYELOID	601626	FLT3	Unknown	—	HPO	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
LEUKEMIA, ACUTE MYELOID	601626	JAK2	Unknown	—	HPO	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
LEUKEMIA, ACUTE MYELOID	601626	KIT	Unknown	—	HPO	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
LEUKEMIA, ACUTE MYELOID	601626	KRAS	Unknown	—	HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
LEUKEMIA, ACUTE MYELOID	601626	LPP	Unknown	—	HPO	—
LEUKEMIA, ACUTE MYELOID	601626	MLLT10	Unknown	—	HPO	—
LEUKEMIA, ACUTE MYELOID	601626	NPM1	Unknown	—	HPO	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
LEUKEMIA, ACUTE MYELOID	601626	NUP214	Unknown	—	HPO	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
LEUKEMIA, ACUTE MYELOID	601626	PICALM	Unknown	—	HPO	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
LEUKEMIA, ACUTE MYELOID	601626	RUNX1	Unknown	—	HPO	Tight junction Th17 cell differentiation Pathways in cancer +20 more
LEUKEMIA, ACUTE MYELOID	601626	SH3GL1	Unknown	—	HPO	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
LEUKEMIA, CHRONIC MYELOID	608232	ABL1	Unknown	—	HPO	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
LEUKEMIA, CHRONIC MYELOID	608232	BCR	Unknown	—	HPO	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
LEUKEMIA, MYELOID	MESH:D007951	AGO2	Unknown	21535412	CTD	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway +11 more
LEUKEMIA, MYELOID	MESH:D007951	ATG2B	Unknown	26280900	CTD	Autophagy - other Autophagy - animal Alzheimer disease +4 more
LEUKEMIA, MYELOID	MESH:D007951	CDO1	Unknown	40369079	CTD	Cysteine and methionine metabolism Taurine and hypotaurine metabolism Metabolic pathways +1 more
LEUKEMIA, MYELOID	MESH:D007951	GSKIP	Unknown	26280900	CTD	—
LEUKEMIA, MYELOID	MESH:D007951	HDAC2	Unknown	21535412	CTD	ATP-dependent chromatin remodeling Polycomb repressive complex Cell cycle +26 more
LEUKEMIA, MYELOID	MESH:D007951	KMT2A	Unknown	17463288 8282816	CTD	Lysine degradation Metabolic pathways Cushing syndrome +4 more
LEUKEMIA, MYELOID	MESH:D007951	KMT2E	Unknown	18854576	CTD	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
LEUKEMIA, MYELOID	MESH:D007951	MECOM	Unknown	23770046	CTD	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
LEUKEMIA, MYELOID	MESH:D007951	NQO1	Unknown	11882782	CTD	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Biosynthesis of cofactors +5 more
LEUKEMIA, MYELOID	MESH:D007951	PRDX2	Unknown	16932348	CTD	Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes
LEUKEMIA, MYELOID	MESH:D007951	RAD21	Unknown	23955599	CTD	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
LEUKEMIA, MYELOID	MESH:D007951	SETBP1	Unknown	23832012	CTD	—
LEUKEMIA, MYELOID	MESH:D007951	SMARCD2	Unknown	28369036	CTD	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
LEUKEMIA, MYELOID	MESH:D007951	SMC1A	Unknown	23955599	CTD	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
LEUKEMIA, MYELOID	MESH:D007951	SMC3	Unknown	23955599	CTD	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
LEUKEMIA, MYELOID	MESH:D007951	SPI1	Unknown	17361223	CTD	Osteoclast differentiation Human T-cell leukemia virus 1 infection Pathways in cancer +3 more
LEUKEMIA, MYELOID	MESH:D007951	STAG2	Unknown	23955599	CTD	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
LEUKEMIA, MYELOID	MESH:D007951	TOP2B	Unknown	16932348	CTD	Platinum drug resistance SUMOylation of DNA replication proteins
LEUKEMIA, MYELOID	MESH:D007951	VEGFA	Unknown	21535412	CTD	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
LEUKEMIA, MYELOID, ACCELERATED PHASE	MESH:D015465	BMI1	Unknown	24571310	CTD	Polycomb repressive complex Signaling pathways regulating pluripotency of stem cells Transcriptional misregulation in cancer +9 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	ADCY7	Unknown	18206229	CTD	Purine metabolism Metabolic pathways Endocrine resistance +58 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	AGRN	Unknown	17330099	CTD	ECM-receptor interaction Cytoskeleton in muscle cells A tetrasaccharide linker sequence is required for GAG synthesis +9 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	ANXA2	Unknown	17330099	CTD	Salmonella infection Neutrophil degranulation Dissolution of Fibrin Clot +1 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	ANXA4	Unknown	17330099	CTD	—
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	ANXA5	Unknown	17330099	CTD	Platelet degranulation
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	ANXA6	Unknown	17330099	CTD	—
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	CBFB	Unknown	18206229 27798625	CTD	RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription +20 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	CEBPA	Unknown	18987666 19822134 30420649	CTD	Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer +3 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	DNMT3A	Unknown	27335278	CTD	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	ETV6	Unknown	—	CTD	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	FLT3	Unknown	17050201 17184839 19822134 21441929 21482694 21928377 22409268 23036488 23906301 24526162 25053825 27099147 27992414	CTD	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	GATA2	Unknown	21892158 21892162	CTD	RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	JAK2	Unknown	16247455	CTD	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	KIT	Unknown	—	CTD	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	KMT2A	Unknown	10339604 26237430	CTD	Lysine degradation Metabolic pathways Cushing syndrome +4 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	KRAS	Unknown	—	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	LPP	Unknown	—	CTD	—
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	MECOM	Unknown	30472098	CTD	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	MLLT10	Unknown	—	CTD	—
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	NPM1	Unknown	19822134 21441929 23877794 27992414 30420649	CTD	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	NUP214	Unknown	—	CTD	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	PICALM	Unknown	—	CTD	Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	RUNX1	Unknown	18206229 27798625 30420649	CTD	Tight junction Th17 cell differentiation Pathways in cancer +20 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	SH3GL1	Unknown	—	CTD	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	SPI1	Unknown	26237430	CTD	Osteoclast differentiation Human T-cell leukemia virus 1 infection Pathways in cancer +3 more
LEUKEMIA, MYELOID, ACUTE	MESH:D015470	TERT	Unknown	—	CTD	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
LEUKEMIA, MYELOID, CHRONIC, ATYPICAL, BCR-ABL NEGATIVE	MESH:D054438	SETBP1	Unknown	23222956	CTD	—

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Myeloid leukemia

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