Moyamoya disease

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

Stimuli-sensing channels

Homologous recombination NOD-like receptor signaling pathway Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +4 more

NF-kappa B signaling pathway

Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Focal adhesion Regulation of actin cytoskeleton Cytoskeleton in muscle cells AGE-RAGE signaling pathway in diabetic complications Shigellosis RHO GTPases Activate Formins ERBB2 Regulates Cell Motility Neutrophil degranulation +5 more

Phospholipase D signaling pathway Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Bacterial invasion of epithelial cells Toll Like Receptor 4 (TLR4) Cascade MHC class II antigen presentation Recycling pathway of L1 Clathrin-mediated endocytosis +6 more

Efferocytosis Focal adhesion Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Bacterial invasion of epithelial cells Shigellosis Yersinia infection Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production +10 more

Factors involved in megakaryocyte development and platelet production

Lysine degradation Metabolic pathways Longevity regulating pathway Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation RNA Polymerase I Transcription Initiation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 +6 more

Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells +1 more

Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction p53 signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Chagas disease African trypanosomiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Lipid and atherosclerosis Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling +36 more

FoxO signaling pathway

Phase 0 - rapid depolarisation

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway PI3K-Akt signaling pathway Focal adhesion Transcriptional misregulation in cancer Rheumatoid arthritis Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization +8 more

Cytoskeleton in muscle cells RHO GTPases Activate Formins

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway Vascular smooth muscle contraction Gap junction Platelet activation Circadian entrainment Long-term depression Oxytocin signaling pathway Renin secretion Salivary secretion +8 more

Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway +3 more

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +25 more

Formation of the cornified envelope

Natural killer cell mediated cytotoxicity Role of LAT2/NTAL/LAB on calcium mobilization

Efferocytosis Cholesterol metabolism Alzheimer disease Malaria Scavenging of heme from plasma Retinoid metabolism and transport +3 more

Rap1 signaling pathway PI3K-Akt signaling pathway

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants +2 more

Renin-angiotensin system Peptide ligand-binding receptors

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Aggrephagy +5 more

Purine metabolism Metabolic pathways Calcium signaling pathway Olfactory transduction Taste transduction Renin secretion Morphine addiction Cam-PDE 1 activation +5 more

Lysine degradation Metabolic pathways Collagen biosynthesis and modifying enzymes

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway Focal adhesion Adherens junction Tight junction Platelet activation Leukocyte transendothelial migration Long-term potentiation Neurotrophin signaling pathway Cushing syndrome Pancreatic secretion Renal cell carcinoma Lipid and atherosclerosis Frs2-mediated activation ARMS-mediated activation Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling MAP2K and MAPK activation Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF MET activates RAP1 and RAC1 Signaling downstream of RAS mutants +28 more

Rap1 signaling pathway cAMP signaling pathway Phospholipase D signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Leukocyte transendothelial migration Insulin secretion Integrin signaling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Rap1 signalling Regulation of insulin secretion +8 more

Antigen processing: Ubiquitination & Proteasome degradation

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Autophagy - other Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Thermogenesis Insulin signaling pathway Shigellosis MicroRNAs in cancer Macroautophagy mTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of PTEN gene transcription Amino acids regulate mTORC1 +16 more

Viral life cycle - HIV-1 Cytosolic DNA-sensing pathway Human immunodeficiency virus 1 infection Nucleobase catabolism Interferon alpha/beta signaling +2 more

RAB GEFs exchange GTP for GDP on RABs

SDK interactions

Homologous recombination NOD-like receptor signaling pathway Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +4 more

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway Vascular smooth muscle contraction Gap junction Platelet activation Circadian entrainment Long-term depression Oxytocin signaling pathway Renin secretion Salivary secretion +8 more

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway Vascular smooth muscle contraction Gap junction Platelet activation Circadian entrainment Long-term depression Oxytocin signaling pathway Renin secretion Salivary secretion +8 more

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway Vascular smooth muscle contraction Gap junction Platelet activation Circadian entrainment Long-term depression Oxytocin signaling pathway Renin secretion Salivary secretion +8 more