Subtype of: Ductal carcinoma of breast · Lobular carcinoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
mixed lobular and ductal breast carcinoma	MONDO_0006306	PPP6C	Unknown	30205045 28481359	Open Targets	COPII-mediated vesicle transport
		PRDM1	Unknown	30205045 28481359	Open Targets	Regulation of TP53 Expression
		PREX2	Unknown	30205045	Open Targets	Regulation of PTEN stability and activity
		PRKCB	Unknown	32723837	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRKD1	Unknown	30205045	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PTCH1	Unknown	30205045 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	30205045 28481359 26960396	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	30205045 28481359	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPRB	Unknown	32723837	Open Targets	Adherens junction Neutrophil degranulation
		PTPRD	Unknown	30205045 28481359	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRT	Unknown	30205045 28481359	Open Targets	—
		RAF1	Unknown	30205045 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RASA1	Unknown	30205045 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	30205045 28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RECQL4	Unknown	30205045 28481359	Open Targets	—
		REL	Unknown	30205045 28481359	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	30205045 28481359	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RICTOR	Unknown	28481359	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		ROS1	Unknown	30205045 28481359	Open Targets	—
		RSPO2	Unknown	32723837	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		RUNX1T1	Unknown	32723837	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		SALL4	Unknown	32723837	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SDHA	Unknown	32723837	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SETD2	Unknown	32723837	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	30205045	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SH2B3	Unknown	30205045 28481359	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SHTN1	Unknown	32723837	Open Targets	—
		SMAD4	Unknown	30205045 28481359	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	30205045	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCD1	Unknown	30205045 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMO	Unknown	30205045 28481359	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SOS1	Unknown	32723837	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	28481359	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPEN	Unknown	30205045 28481359	Open Targets	Notch signaling pathway
		SPOP	Unknown	30205045 28481359	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SRC	Unknown	27095739	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		SRSF2	Unknown	30205045 28481359	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		STAT5B	Unknown	30205045	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STK11	Unknown	30205045 28481359	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		SUZ12	Unknown	30205045 28481359	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		TBX3	Unknown	30205045 28921573 28481359 32723837	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCF7L2	Unknown	30205045 28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TET1	Unknown	30205045 28481359 32723837	Open Targets	—
		TET2	Unknown	30205045 28481359	Open Targets	—
		TGFBR2	Unknown	30205045 28481359	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TNRC18	Unknown	32723837	Open Targets	—
		TP53	Unknown	30205045 25009010 30531871 32723837 27095739 28481359	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TSC1	Unknown	25009010	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	30205045 28481359 32723837	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		U2AF1	Unknown	30205045 28481359	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more

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Mixed lobular and ductal breast carcinoma

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