Mitral valve prolapse

Antigen processing: Ubiquitination & Proteasome degradation

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Regulation of HSF1-mediated heat shock response

Spliceosome

Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway +4 more

HDMs demethylate histones TFAP2 (AP-2) family regulates transcription of cell cycle factors

Surfactant metabolism

Molecules associated with elastic fibres

Molecules associated with elastic fibres

Protein repair

Cytoskeleton in muscle cells RET signaling

PI and PC transport between ER and Golgi membranes

Vascular smooth muscle contraction Focal adhesion Regulation of actin cytoskeleton Oxytocin signaling pathway Proteoglycans in cancer Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PAKs +5 more

mRNA surveillance pathway Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Cytoskeleton in muscle cells NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport +2 more

Toxicity of botulinum toxin type B (BoNT/B) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors

Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils +1 more

Hippo signaling pathway - multiple species

Hedgehog 'on' state

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Pathways in cancer Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +18 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Axon guidance Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells MicroRNAs in cancer Fluid shear stress and atherosclerosis Signaling by BMP +5 more

Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization +10 more

Hippo signaling pathway - multiple species

Hedgehog 'on' state

TGF-beta signaling pathway Cytoskeleton in muscle cells Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +5 more

MAPK signaling pathway Focal adhesion Salmonella infection Proteoglycans in cancer Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response +6 more

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions Neutrophil degranulation Interferon gamma signaling Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +24 more

Surfactant metabolism

Molecules associated with elastic fibres

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Autophagy - animal Efferocytosis mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Cellular senescence Vascular smooth muscle contraction VEGF signaling pathway Apelin signaling pathway Gap junction Signaling pathways regulating pluripotency of stem cells Neutrophil extracellular trap formation Toll-like receptor signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Long-term potentiation Neurotrophin signaling pathway Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Estrogen signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway Relaxin signaling pathway GnRH secretion Cushing syndrome Growth hormone synthesis, secretion and action Alzheimer disease Pathways of neurodegeneration - multiple diseases Salmonella infection Yersinia infection Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer MAPK1 (ERK2) activation Frs2-mediated activation Signal transduction by L1 Uptake and function of anthrax toxins RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +87 more

Steroid biosynthesis Metabolic pathways Cholesterol biosynthesis

Cytoskeleton in muscle cells RET signaling

NF-kappa B signaling pathway Complement and coagulation cascades Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Neutrophil degranulation Dissolution of Fibrin Clot +5 more

Lysine degradation Metabolic pathways Collagen biosynthesis and modifying enzymes

MAPK signaling pathway Oocyte meiosis mTOR signaling pathway Thermogenesis Long-term potentiation Neurotrophin signaling pathway Progesterone-mediated oocyte maturation Insulin resistance Yersinia infection Chemical carcinogenesis - receptor activation ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation Gastrin-CREB signalling pathway via PKC and MAPK +13 more

Alzheimer disease Parkinson disease

Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Thyroid hormone synthesis Regulation of lipolysis in adipocytes Autoimmune thyroid disease Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +6 more

Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy Platelet degranulation Striated Muscle Contraction +2 more

Hippo signaling pathway - multiple species

Hedgehog 'on' state