Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
melanocytic neoplasm	MONDO_0021143	ALK	Unknown	24445538 24698967	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		BAP1	Unknown	21874003 22367297	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BLM	Unknown	32701692	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BRAF	Unknown	26061100 19438459 21482913 21874003 21496703 24445538 22367297	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CALR	Unknown	32701692	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CDKN2A	Unknown	20860655 26061100	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CEP89	Unknown	24445538	Open Targets	Anchoring of the basal body to the plasma membrane
		CLIP1	Unknown	24445538	Open Targets	mTOR signaling pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		DCTN1	Unknown	24445538	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		ERC1	Unknown	24445538	Open Targets	NF-kappa B signaling pathway
		FGFR2	Unknown	32701692	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FLT4	Unknown	32701692	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		GOLGA5	Unknown	24445538	Open Targets	Intra-Golgi traffic
		HLA-A	Unknown	24445538	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HRAS	Unknown	21496703 20871217 19438459 24445538 21482913	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH1	Unknown	32732488	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IRF4	Unknown	32701692	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		KIF5B	Unknown	24445538	Open Targets	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KMT2D	Unknown	32701692	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		LMNA	Unknown	24445538	Open Targets	Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy +8 more
		LSM14A	Unknown	24445538	Open Targets	—
		MDM2	Unknown	32701692	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MITF	Unknown	32701692	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MYO5A	Unknown	24445538	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		NF1	Unknown	32701692	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	32701692	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NRAS	Unknown	32732488 19438459 25263998	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK1	Unknown	24445538	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		PPFIBP1	Unknown	24445538	Open Targets	Receptor-type tyrosine-protein phosphatases
		PTEN	Unknown	26061100	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PWWP2A	Unknown	24445538	Open Targets	—
		RET	Unknown	24445538	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		ROS1	Unknown	24445538	Open Targets	—
		SHTN1	Unknown	24445538	Open Targets	—
		SUFU	Unknown	32701692	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		TP53	Unknown	24445538	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TPM3	Unknown	24445538 24698967	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		ZCCHC8	Unknown	24445538	Open Targets	—

Melanocytic neoplasm

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