Subtype of: Lymphoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
marginal zone lymphoma	MONDO_0017604	KMT2D	Unknown	27248180 29556019 24349473 22891273	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	22891273	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		LRP1B	Unknown	22891273	Open Targets	—
		MAP2K1	Unknown	22891273	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MED12	Unknown	29481902	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MLH1	Unknown	27248180	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MSH2	Unknown	27248180	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MUC16	Unknown	24349473	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	24349473	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYD88	Unknown	23611359 22931316 23532735 25088352 22944768 24072850 23355535 25972321 25723115 24135828 27861728 23378931 23446312 22102703 23321251 29556019 22891273 25819228 26498442 23955458	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYOD1	Unknown	27248180	Open Targets	Spinocerebellar ataxia Myogenesis
		NCOR2	Unknown	29481902	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NF1	Unknown	27248180	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFKBIE	Unknown	25987724 29481902	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway +6 more
		NOTCH1	Unknown	28633365 22891273 28481359 29556019	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	27248180 22891276 18508802 25088352 24349473 29556019 22891273 26498442	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NPM1	Unknown	27248180	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NUP98	Unknown	22891273	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PCM1	Unknown	22891273	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PIK3R1	Unknown	27248180	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLCG1	Unknown	29556019	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PTCH1	Unknown	27248180	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	29556019	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRB	Unknown	24349473	Open Targets	Adherens junction Neutrophil degranulation
		PTPRD	Unknown	22891273	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	22891273	Open Targets	EGFR downregulation
		RAD50	Unknown	27248180	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RASA1	Unknown	24349473	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RHOA	Unknown	27248180	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RMI2	Unknown	29556019 29481902	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		ROBO2	Unknown	22891273	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		SOCS1	Unknown	29556019 29481902	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SPEN	Unknown	22891273 24349473 29556019 29481902	Open Targets	Notch signaling pathway
		SRSF2	Unknown	29386642	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		STAG1	Unknown	22891273	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		TBL1XR1	Unknown	27248180 29556019 29481902 22891273	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TET2	Unknown	29386642	Open Targets	—
		TNFAIP3	Unknown	27248180 19258598 25088352 24349473 29556019 22102703 22891273 21881048 28481359	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNFRSF14	Unknown	29556019	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TP53	Unknown	22891273 8579126 29556019	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TRRAP	Unknown	22891273 24349473	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		XPC	Unknown	24349473	Open Targets	Nucleotide excision repair SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER +1 more
		XPO1	Unknown	28481359	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more

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Marginal zone lymphoma

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