Subtype of: Mesothelioma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
malignant epithelioid mesothelioma	MONDO_0005599	APC	Unknown	26070481	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	27127140	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARID1A	Unknown	27813512	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASXL1	Unknown	27127140	Open Targets	Polycomb repressive complex UCH proteinases
		BAP1	Unknown	28034829 26070481 32504035 27187383 27127140 25889843 27813512	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BRCA1	Unknown	26070481	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	26070481	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CDK12	Unknown	27127140	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDKN2A	Unknown	32504035 26070481 24474244	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		DAXX	Unknown	27127140	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DDX3X	Unknown	25889843 27813512	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		EGFR	Unknown	22412050	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ESR1	Unknown	27127140	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		EWSR1	Unknown	23630070	Open Targets	Transcriptional misregulation in cancer
		JAK1	Unknown	27127140	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		KDM6A	Unknown	27127140	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	27127140	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KEAP1	Unknown	27127140	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		LATS2	Unknown	26070481	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LOC100506403	Unknown	25889843	Open Targets	—
		MET	Unknown	27127140	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MTOR	Unknown	27127140	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MYC	Unknown	25889843	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		NF2	Unknown	32504035 25798586 27127140 27813512	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NOTCH2	Unknown	27187383	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		PBRM1	Unknown	32504035	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PTPRD	Unknown	25889843	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		RAD51B	Unknown	25889843	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		SETD2	Unknown	32504035 27813512	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		TFPT	Unknown	25798586	Open Targets	ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER
		TP53	Unknown	32504035 26070481	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TRAF7	Unknown	32504035	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TSC1	Unknown	32504035 27127140	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		WT1	Unknown	27813512	Open Targets	Transcriptional misregulation in cancer

Malignant epithelioid mesothelioma

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