Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
malignant conjunctival melanoma	MONDO_0002096	ALK	Unknown	28481359 31647501	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AR	Unknown	28481359	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARID1A	Unknown	31320640 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ATM	Unknown	31647501	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATRX	Unknown	28481359 31647501	Open Targets	Cell cycle
		BCOR	Unknown	28481359	Open Targets	Polycomb repressive complex
		BRAF	Unknown	19018266 28481359 24815010 21693616 23014346 25722211 23799844 22536370 16123397 15277467 23633454 22406360 31320640 31647501 25595173 36830931 24166902	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	28481359	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CALR	Unknown	31320640	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CBL	Unknown	31647501	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CIC	Unknown	28481359 31647501	Open Targets	Spinocerebellar ataxia
		CTNNB1	Unknown	21356389 31320640	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		EP300	Unknown	28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		ERBB4	Unknown	31647501	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERCC2	Unknown	28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		FAT1	Unknown	28481359	Open Targets	—
		FBXW7	Unknown	31647501	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR2	Unknown	31647501	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		GNAS	Unknown	31320640	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		JAK3	Unknown	28481359	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KIT	Unknown	23633454 25595173 19718013 23014346 18980976	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2C	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KRAS	Unknown	29266020	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LRP1B	Unknown	31320640	Open Targets	—
		NCOA2	Unknown	31320640	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NF1	Unknown	28481359 31647501	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NRAS	Unknown	25722211 23799844 23633454 31647501 31320640 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NUP98	Unknown	31320640	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Influenza A +33 more
		PDGFRB	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PIK3CB	Unknown	31647501	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PPP6C	Unknown	28481359 31647501	Open Targets	COPII-mediated vesicle transport
		PREX2	Unknown	31647501	Open Targets	Regulation of PTEN stability and activity
		PTEN	Unknown	28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRT	Unknown	28481359	Open Targets	—
		RET	Unknown	31320640	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		ROS1	Unknown	28481359	Open Targets	—
		SETD2	Unknown	30847022	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	30847022	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SFPQ	Unknown	31320640	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		TP53	Unknown	28481359 31647501	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more

Malignant conjunctival melanoma

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