Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ACUTE LYMPHOBLASTIC LEUKEMIA	MONDO:0004967	SH2B3	Unknown	—	GenCC	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA	MONDO_0000870	AIG1	Unknown	22076464	GWAS catalog	—
		ARID5B	Unknown	19684603 19684604 22076464 23512250 25310577 28817678 29348612 33891562	GWAS catalog	HDMs demethylate histones
		CDKN2B	Unknown	29348612	GWAS catalog	FoxO signaling pathway Cell cycle Cellular senescence +12 more
		CEBPE	Unknown	19684604 22076464 23512250 29348612	GWAS catalog	Transcriptional misregulation in cancer Acute myeloid leukemia
		CFHR1	Unknown	19684603	GWAS catalog	Complement and coagulation cascades Regulation of Complement cascade
		CFHR4	Unknown	19684603	GWAS catalog	Complement and coagulation cascades Regulation of Complement cascade
		CIROP	Unknown	23512250	GWAS catalog	—
		CSGALNACT1	Unknown	22076464	GWAS catalog	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Metabolic pathways Chondroitin sulfate biosynthesis
		DDC	Unknown	22076464	GWAS catalog	Tyrosine metabolism Phenylalanine metabolism Tryptophan metabolism +8 more
		ERC2	Unknown	22076464	GWAS catalog	—
		GCSAML	Unknown	19684603	GWAS catalog	—
		GPATCH2L	Unknown	22076464	GWAS catalog	—
		GSDMB	Unknown	29348612	GWAS catalog	—
		HTR1B	Unknown	22076464	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		IKZF1	Unknown	19684603 19684604 22076464 23512250 25310577 29348612	GWAS catalog	—
		INTS10	Unknown	22076464	GWAS catalog	RNA polymerase II transcribes snRNA genes
		KCNA3	Unknown	22076464	GWAS catalog	Voltage gated Potassium channels
		KCNE4	Unknown	19684603	GWAS catalog	Phase 3 - rapid repolarisation Phase 2 - plateau phase
		KCNMB2	Unknown	19684603	GWAS catalog	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +1 more
		KLHL5	Unknown	28817678	GWAS catalog	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		LHPP	Unknown	29348612	GWAS catalog	Oxidative phosphorylation Purine ribonucleoside monophosphate biosynthesis
		LYPD6	Unknown	23007406	GWAS catalog	Neuroactive ligand-receptor interaction
		MAGI2	Unknown	23007406	GWAS catalog	Rap1 signaling pathway PI3K-Akt signaling pathway
		MAP1LC3B2	Unknown	19684603	GWAS catalog	Mitophagy - animal Autophagy - animal Ferroptosis +6 more
		METTL4	Unknown	19684603	GWAS catalog	—
		MMADHC	Unknown	23007406	GWAS catalog	Cobalamin transport and metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
		MYRIP	Unknown	23007406	GWAS catalog	—
		NPFFR1	Unknown	23007406	GWAS catalog	Neuroactive ligand-receptor interaction Orexin and neuropeptides FF and QRFP bind to their respective receptors G alpha (q) signalling events
		OR2C3	Unknown	19684603	GWAS catalog	Olfactory transduction Olfactory Signaling Pathway
		OR5AL1	Unknown	22076464	GWAS catalog	Olfactory transduction
		PARD3	Unknown	19684603	GWAS catalog	Rap1 signaling pathway Chemokine signaling pathway Endocytosis +7 more
		PDE4B	Unknown	22076464 23007406	GWAS catalog	Purine metabolism Metabolic pathways cAMP signaling pathway +3 more
		PIP4K2A	Unknown	29348612	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +5 more
		PTPRJ	Unknown	22076464	GWAS catalog	Adherens junction Chemical carcinogenesis - reactive oxygen species Phosphorylation of CD3 and TCR zeta chains +2 more
		PYGL	Unknown	23007406	GWAS catalog	Starch and sucrose metabolism Metabolic pathways Necroptosis +5 more
		RIT2	Unknown	23007406	GWAS catalog	—
		RSPO2	Unknown	22076464	GWAS catalog	Wnt signaling pathway Regulation of FZD by ubiquitination
		RXFP1	Unknown	22076464	GWAS catalog	Neuroactive ligand-receptor interaction Relaxin signaling pathway G alpha (s) signalling events +2 more
		RYR2	Unknown	19684603	GWAS catalog	Calcium signaling pathway cAMP signaling pathway Cardiac muscle contraction +14 more
		SLCO3A1	Unknown	22076464	GWAS catalog	Transport of organic anions
		SP4	Unknown	29348612	GWAS catalog	—
		ST6GALNAC3	Unknown	19684603	GWAS catalog	Mucin type O-glycan biosynthesis Glycosphingolipid biosynthesis - ganglio series Metabolic pathways +2 more
		TBXAS1	Unknown	23007406	GWAS catalog	Arachidonic acid metabolism Metabolic pathways Platelet activation +3 more
		TIGAR	Unknown	19684603	GWAS catalog	Fructose and mannose metabolism Metabolic pathways Central carbon metabolism in cancer +1 more
		TP63	Unknown	22076464	GWAS catalog	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		WDR19	Unknown	28817678	GWAS catalog	Hedgehog 'off' state Intraflagellar transport
		ZNF230	Unknown	19684603	GWAS catalog	Generic Transcription Pathway
LEUKEMIA, ACUTE LYMPHOBLASTIC	613065	BAX	Unknown	—	HPO	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more
LEUKEMIA, ACUTE LYMPHOBLASTIC	613065	BCR	Unknown	—	HPO	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
LEUKEMIA, ACUTE LYMPHOCYTIC, SUSCEPTIBILITY TO, 1	MONDO:0013108	BAX	Unknown	—	GenCC	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more

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Lymphoblastic leukemia

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