Lung cancer

Endocrine resistance Platinum drug resistance MAPK signaling pathway Sphingolipid signaling pathway Cell cycle p53 signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Ferroptosis Cellular senescence Wnt signaling pathway Neurotrophin signaling pathway Thyroid hormone signaling pathway Parkinson disease Amyotrophic lateral sclerosis Huntington disease Shigellosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription +85 more

Chemokine receptors bind chemokines

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

Endocytosis Tight junction Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis +12 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Signaling by Activin +1 more

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway Measles Influenza A Coronavirus disease - COVID-19 C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling +5 more

Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism Pyruvate metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Alcoholic liver disease Ethanol oxidation +7 more

Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism Pyruvate metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Alcoholic liver disease RA biosynthesis pathway Ethanol oxidation +8 more

Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications Alzheimer disease Pathways of neurodegeneration - multiple diseases Diabetic cardiomyopathy Lipid and atherosclerosis TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

Th17 cell differentiation Cushing syndrome Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling +6 more

Purine metabolism Thiamine metabolism Metabolic pathways Nucleotide metabolism Biosynthesis of cofactors Interconversion of nucleotide di- and triphosphates +3 more

Pentose and glucuronate interconversions Fructose and mannose metabolism Galactose metabolism Glycerolipid metabolism Folate biosynthesis Metabolic pathways Retinoid metabolism and transport +4 more

HuR (ELAVL1) binds and stabilizes mRNA

Retinoid metabolism and transport

Vasopressin-regulated water reabsorption Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins

PPAR signaling pathway Regulation of lipolysis in adipocytes Transport of glycerol from adipocytes to the liver by Aquaporins Passive transport by Aquaporins +1 more

Rap1 signaling pathway cAMP signaling pathway Endocytosis Rho GTPase cycle +1 more

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Taste transduction Inflammatory mediator regulation of TRP channels Stimuli-sensing channels

Melanogenesis

Platinum drug resistance Homologous recombination NF-kappa B signaling pathway FoxO signaling pathway Cell cycle p53 signaling pathway Apoptosis Cellular senescence Shigellosis Human papillomavirus infection Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection Transcriptional misregulation in cancer MicroRNAs in cancer DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Pexophagy +33 more

Ion transport by P-type ATPases

Neutrophil degranulation Ion transport by P-type ATPases

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Miscellaneous transport and binding events

Mannose type O-glycan biosynthesis Metabolic pathways A tetrasaccharide linker sequence is required for GAG synthesis

Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +3 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Autophagy - animal PI3K-Akt signaling pathway Apoptosis VEGF signaling pathway Focal adhesion Neurotrophin signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human papillomavirus infection Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Lipid and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Constitutive Signaling by AKT1 E17K in Cancer +44 more

Protein export

ATP-dependent chromatin remodeling

EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Non-alcoholic fatty liver disease Epstein-Barr virus infection Pathways in cancer MicroRNAs in cancer Colorectal cancer Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription +13 more

Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Legionellosis Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Viral myocarditis Lipid and atherosclerosis Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 +53 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Toxoplasmosis Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Laminin interactions MET activates PTK2 signaling +12 more

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange +3 more

Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Legionellosis Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Viral myocarditis Lipid and atherosclerosis Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 +53 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Toxoplasmosis Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Laminin interactions MET activates PTK2 signaling +12 more

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange +3 more

Endocrine resistance Platinum drug resistance MAPK signaling pathway Sphingolipid signaling pathway Cell cycle p53 signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Ferroptosis Cellular senescence Wnt signaling pathway Neurotrophin signaling pathway Thyroid hormone signaling pathway Parkinson disease Amyotrophic lateral sclerosis Huntington disease Shigellosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription +85 more

Chemokine receptors bind chemokines

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

Endocytosis Tight junction Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis +12 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Signaling by Activin +1 more

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway Measles Influenza A Coronavirus disease - COVID-19 C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling +5 more

Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism Pyruvate metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Alcoholic liver disease Ethanol oxidation +7 more

Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism Pyruvate metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Alcoholic liver disease RA biosynthesis pathway Ethanol oxidation +8 more

Purine metabolism Thiamine metabolism Metabolic pathways Nucleotide metabolism Biosynthesis of cofactors Interconversion of nucleotide di- and triphosphates +3 more

Retinoid metabolism and transport

Rap1 signaling pathway cAMP signaling pathway Endocytosis Rho GTPase cycle +1 more

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Melanogenesis

Ion transport by P-type ATPases

Neutrophil degranulation Ion transport by P-type ATPases

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Miscellaneous transport and binding events

Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +3 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Autophagy - animal PI3K-Akt signaling pathway Apoptosis VEGF signaling pathway Focal adhesion Neurotrophin signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human papillomavirus infection Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Lipid and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Constitutive Signaling by AKT1 E17K in Cancer +44 more

Protein export

EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Non-alcoholic fatty liver disease Epstein-Barr virus infection Pathways in cancer MicroRNAs in cancer Colorectal cancer Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription +13 more

Chemokine receptors bind chemokines

Vascular smooth muscle contraction Apelin signaling pathway Motor proteins Relaxin signaling pathway Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription +3 more

Endocytosis Tight junction Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Bacterial invasion of epithelial cells Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis +12 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Signaling by Activin +1 more

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway Measles Influenza A Coronavirus disease - COVID-19 C6 deamination of adenosine Formation of editosomes by ADAR proteins Interferon alpha/beta signaling +5 more

Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism Pyruvate metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Alcoholic liver disease Ethanol oxidation +7 more

Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism Pyruvate metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Alcoholic liver disease RA biosynthesis pathway Ethanol oxidation +8 more

Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications Alzheimer disease Pathways of neurodegeneration - multiple diseases Diabetic cardiomyopathy Lipid and atherosclerosis TAK1 activates NFkB by phosphorylation and activation of IKKs complex Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation +7 more

Th17 cell differentiation Cushing syndrome Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling +6 more

Purine metabolism Thiamine metabolism Metabolic pathways Nucleotide metabolism Biosynthesis of cofactors Interconversion of nucleotide di- and triphosphates +3 more

Retinoid metabolism and transport

Rap1 signaling pathway cAMP signaling pathway Endocytosis Rho GTPase cycle +1 more

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Melanogenesis

Ion transport by P-type ATPases

Neutrophil degranulation Ion transport by P-type ATPases

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Miscellaneous transport and binding events

Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +3 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Autophagy - animal PI3K-Akt signaling pathway Apoptosis VEGF signaling pathway Focal adhesion Neurotrophin signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human papillomavirus infection Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Lipid and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Constitutive Signaling by AKT1 E17K in Cancer +44 more

Protein export

EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Non-alcoholic fatty liver disease Epstein-Barr virus infection Pathways in cancer MicroRNAs in cancer Colorectal cancer Activation of BIM and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Signaling by BRAF and RAF fusions Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription +13 more

Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Legionellosis Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Viral myocarditis Lipid and atherosclerosis Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 +53 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Toxoplasmosis Amoebiasis Human papillomavirus infection Pathways in cancer Small cell lung cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis Laminin interactions MET activates PTK2 signaling +12 more

Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange +3 more

Endocrine resistance Platinum drug resistance MAPK signaling pathway Sphingolipid signaling pathway Cell cycle p53 signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Ferroptosis Cellular senescence Wnt signaling pathway Neurotrophin signaling pathway Thyroid hormone signaling pathway Parkinson disease Amyotrophic lateral sclerosis Huntington disease Shigellosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription +85 more