Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CIRRHOSIS OF LIVER	EFO_0001422	ALDH2	Unknown	34594039	GWAS catalog	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		APOC1	Unknown	38632349 39024449	GWAS catalog	Cholesterol metabolism VLDL assembly VLDL clearance +1 more
		APOE	Unknown	38632349 39024449	GWAS catalog	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
		CACNA2D1	Unknown	20708005	GWAS catalog	MAPK signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes +7 more
		CDH2	Unknown	20708005	GWAS catalog	Cell adhesion molecules Arrhythmogenic right ventricular cardiomyopathy Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +3 more
		CHD9NB	Unknown	34441435	GWAS catalog	—
		CHST2	Unknown	20708005	GWAS catalog	Glycosaminoglycan biosynthesis - keratan sulfate Keratan sulfate biosynthesis
		CNTN5	Unknown	20708005	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		COL13A1	Unknown	20708005	GWAS catalog	Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes +2 more
		COQ3	Unknown	34441435	GWAS catalog	Ubiquinone and other terpenoid-quinone biosynthesis Metabolic pathways Biosynthesis of cofactors +1 more
		CRACR2A	Unknown	20708005	GWAS catalog	Neutrophil degranulation
		DCLK1	Unknown	23535911	GWAS catalog	—
		DDX60L	Unknown	20708005	GWAS catalog	—
		EEF1A2	Unknown	34441435	GWAS catalog	Nucleocytoplasmic transport Legionellosis Leishmaniasis
		EHBP1L1	Unknown	20708005	GWAS catalog	—
		FARP1	Unknown	20708005	GWAS catalog	—
		FAXC	Unknown	34441435	GWAS catalog	—
		FDFT1	Unknown	20708005	GWAS catalog	Steroid biosynthesis Metabolic pathways Cholesterol biosynthesis +2 more
		GC	Unknown	23213074	GWAS catalog	Vitamin D (calciferol) metabolism
		GLT8D2	Unknown	22841784	GWAS catalog	—
		HDAC9	Unknown	34594039	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +3 more
		HERPUD2	Unknown	20708005	GWAS catalog	—
		HKDC1	Unknown	38632349	GWAS catalog	Glycolysis / Gluconeogenesis Fructose and mannose metabolism Galactose metabolism +12 more
		HLA-B	Unknown	34594039	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DPB1	Unknown	37601966	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB1	Unknown	39024449	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HSD17B13	Unknown	38632349 39024449	GWAS catalog	Lipid particle organization
		IFNL4	Unknown	39024449	GWAS catalog	—
		JCAD	Unknown	20708005	GWAS catalog	—
		KHDRBS3	Unknown	20708005	GWAS catalog	PTK6 Regulates Proteins Involved in RNA Processing
		KLHL8	Unknown	33310085	GWAS catalog	—
		LCP1	Unknown	23213074	GWAS catalog	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		MACROD2	Unknown	20708005	GWAS catalog	—
		MAN1A1	Unknown	34441435	GWAS catalog	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +3 more
		MAPKAPK5	Unknown	32514122	GWAS catalog	MAPK signaling pathway Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling +1 more
		MERTK	Unknown	22841784	GWAS catalog	Efferocytosis Cell surface interactions at the vascular wall
		MLXIPL	Unknown	34441435	GWAS catalog	Insulin resistance Non-alcoholic fatty liver disease PKA-mediated phosphorylation of key metabolic factors +1 more
		MTARC1	Unknown	33310085 38632349 39024449	GWAS catalog	Phase I - Functionalization of compounds
		MTCL1	Unknown	34441435	GWAS catalog	—
		NDST4	Unknown	34441435	GWAS catalog	Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis
		NFIC	Unknown	20708005	GWAS catalog	—
		PCSK5	Unknown	20708005	GWAS catalog	NGF processing Assembly of active LPL and LIPC lipase complexes
		PDCD6	Unknown	34441435	GWAS catalog	—
		PKD1L1	Unknown	22841784	GWAS catalog	—
		PLPPR4	Unknown	23213074	GWAS catalog	Lysosphingolipid and LPA receptors
		PLXNA2	Unknown	34441435	GWAS catalog	Axon guidance Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion +1 more
		PNPLA3	Unknown	23535911 31815349 32514122 33310085 34594039 37965154 38632349 39024449 40465716	GWAS catalog	Glycerolipid metabolism Metabolic pathways Acyl chain remodeling of DAG and TAG
		RNF7	Unknown	22841784	GWAS catalog	Ubiquitin mediated proteolysis Human immunodeficiency virus 1 infection Neddylation +1 more
		SEL1L3	Unknown	20708005	GWAS catalog	—
		SERPINA1	Unknown	33310085 37965154 38632349 39024449	GWAS catalog	Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport +4 more
LIVER CIRRHOSIS	C0023890 MESH:D008103	GC	Unknown	24381012	CTD, Disgenet	Vitamin D (calciferol) metabolism
		HLA-DQB1	Unknown	—	Disgenet	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		IFNL4	Unknown	—	Disgenet	—
		PNPLA3	Unknown	—	Disgenet	Glycerolipid metabolism Metabolic pathways Acyl chain remodeling of DAG and TAG
		SERPINA1	Unknown	20511674 25579632 3485248	CTD, Disgenet	Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport +4 more
LIVER CIRRHOSIS, ALCOHOLIC	C0023891 MESH:D008104	ALDH2	Unknown	—	Disgenet	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
LIVER CIRRHOSIS, ALCOHOLIC	C0023891 MESH:D008104	PNPLA3	Unknown	19946271 26482880	CTD, Disgenet	Glycerolipid metabolism Metabolic pathways Acyl chain remodeling of DAG and TAG

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Liver cirrhosis

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