Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
LEARNING DISABILITIES	C0751265 MESH:D007859	ACHE	Unknown	18533140	CTD, Disgenet	Glycerophospholipid metabolism Cholinergic synapse Neurotransmitter clearance +2 more
		APOD	Unknown	18419796	CTD, Disgenet	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
		APP	Unknown	16474004 18533140 20816828 22484447 25213453 26420483 27306655 29729307 35247505	CTD, Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		BCL2	Unknown	17967740	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		CAMKMT	Unknown	26247364	CTD, Disgenet	Lysine degradation Metabolic pathways Inactivation, recovery and regulation of the phototransduction cascade +1 more
		FIBP	Unknown	—	Disgenet	—
		GRIA1	Unknown	16495937	CTD, Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment +18 more
		HMOX1	Unknown	11718997	CTD, Disgenet	Porphyrin metabolism Metabolic pathways HIF-1 signaling pathway +11 more
		HTR1A	Unknown	12591222	CTD, Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		HTR7	Unknown	21859099	CTD, Disgenet	Ras signaling pathway Calcium signaling pathway Neuroactive ligand-receptor interaction +4 more
		IGF1	Unknown	34632857	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +35 more
		IKBKG	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Ras signaling pathway +76 more
		IL1B	Unknown	21290410	CTD, Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +47 more
		IL1RN	Unknown	25665855	CTD, Disgenet	Cytokine-cytokine receptor interaction Interleukin-10 signaling Interleukin-1 signaling
		KL	Unknown	25309793	CTD, Disgenet	Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Metabolic pathways +15 more
		MAPT	Unknown	24556215	CTD, Disgenet	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		MECP2	Unknown	19921286	CTD, Disgenet	Transcriptional Regulation by MECP2 Loss of MECP2 binding ability to 5hmC-DNA Loss of MECP2 binding ability to 5mC-DNA +2 more
		MEIS2	Unknown	—	Disgenet	—
		MICU1	Unknown	24336167	CTD, Disgenet	Mitochondrial calcium ion transport Processing of SMDT1
		MT1A	Unknown	—	Disgenet	Mineral absorption Metallothioneins bind metals
		MT2A	Unknown	—	Disgenet	Mineral absorption Metallothioneins bind metals Interferon gamma signaling
		NF1	Unknown	21949590	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		PDE1B	Unknown	12077213	CTD, Disgenet	Purine metabolism Metabolic pathways Calcium signaling pathway +7 more
		PNOC	Unknown	10401555	CTD, Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +1 more
		POR	Unknown	21987461	CTD, Disgenet	Cytochrome P450 - arranged by substrate type
		PRKN	Unknown	12915482	CTD, Disgenet	Ubiquitin mediated proteolysis Mitophagy - animal Protein processing in endoplasmic reticulum +8 more
		PSEN1	Unknown	25213453	CTD, Disgenet	Wnt signaling pathway Notch signaling pathway Neurotrophin signaling pathway +12 more
		SIGMAR1	Unknown	15451042	CTD	Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases
		SLC17A6	Unknown	21295146	CTD, Disgenet	Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse +2 more
		SLC17A7	Unknown	21295146	CTD, Disgenet	Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse +3 more
		SYP	Unknown	21295146	CTD, Disgenet	—
		TH	Unknown	10984662 9822156	CTD, Disgenet	Tyrosine metabolism Folate biosynthesis Metabolic pathways +7 more
		TLR4	Unknown	29107071	CTD, Disgenet	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
		TRH	Unknown	8405091	CTD, Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +1 more
		VEGFA	Unknown	20801723	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
LEARNING DISABILITY	MONDO_0004681	KCNIP4	Unknown	40465716	GWAS catalog	Phase 1 - inactivation of fast Na+ channels
LEARNING DISORDERS	C0023186	ACHE	Unknown	—	Disgenet	Glycerophospholipid metabolism Cholinergic synapse Neurotransmitter clearance +2 more
		APOD	Unknown	—	Disgenet	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
		APP	Unknown	—	Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		BCL2	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
		CAMKMT	Unknown	—	Disgenet	Lysine degradation Metabolic pathways Inactivation, recovery and regulation of the phototransduction cascade +1 more
		GRIA1	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Circadian entrainment +18 more
		HMOX1	Unknown	—	Disgenet	Porphyrin metabolism Metabolic pathways HIF-1 signaling pathway +11 more
		HTR1A	Unknown	—	Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Serotonergic synapse +3 more
		HTR7	Unknown	—	Disgenet	Ras signaling pathway Calcium signaling pathway Neuroactive ligand-receptor interaction +4 more
		IGF1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +35 more
		IKBKG	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Ras signaling pathway +76 more
		IL1B	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +47 more
		IL1RN	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Interleukin-10 signaling Interleukin-1 signaling
		KL	Unknown	—	Disgenet	Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Metabolic pathways +15 more
		MAPT	Unknown	—	Disgenet	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		MECP2	Unknown	—	Disgenet	Transcriptional Regulation by MECP2 Loss of MECP2 binding ability to 5hmC-DNA Loss of MECP2 binding ability to 5mC-DNA +2 more
		MEIS2	Unknown	—	Disgenet	—
		MICU1	Unknown	—	Disgenet	Mitochondrial calcium ion transport Processing of SMDT1
		MT1A	Unknown	—	Disgenet	Mineral absorption Metallothioneins bind metals
		MT2A	Unknown	—	Disgenet	Mineral absorption Metallothioneins bind metals Interferon gamma signaling
		NF1	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		PDE1B	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Calcium signaling pathway +7 more
		PNOC	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +1 more
		POR	Unknown	—	Disgenet	Cytochrome P450 - arranged by substrate type
		PRKN	Unknown	—	Disgenet	Ubiquitin mediated proteolysis Mitophagy - animal Protein processing in endoplasmic reticulum +8 more
		PSEN1	Unknown	—	Disgenet	Wnt signaling pathway Notch signaling pathway Neurotrophin signaling pathway +12 more
		SLC17A6	Unknown	—	Disgenet	Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse +2 more
		SLC17A7	Unknown	—	Disgenet	Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse +3 more
		SYP	Unknown	—	Disgenet	—
		TH	Unknown	—	Disgenet	Tyrosine metabolism Folate biosynthesis Metabolic pathways +7 more
		TLR4	Unknown	—	Disgenet	NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome +41 more
		TRH	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors +1 more
		VEGFA	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more

Learning disorders

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