Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Lagerhans cell histiocytosis	MONDO_0018310	BRAF	Unknown	26287849	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
Langerhans cell histiocytosis	MONDO_0018310	ARAF	Unknown	24652991	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARID1A	Unknown	32918521	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ATM	Unknown	28481359	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		BRAF	Unknown	24471909 24652991 24648950 25156525 23287985 25268199 24982505 25745636 24638167 20519626 25323687 29649018 31072207 23258922 24894769 25118810 24703101 34301788 24938183 22996177 25899310 30923995 25858893 22506009 23782385 22859608 25202140 25948218 24720374 28679432 25128147 22879539 25351766 26085387 26110571 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	28481359	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRD4	Unknown	28481359	Open Targets	—
		CDKN2A	Unknown	32918521	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CREBBP	Unknown	28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		DNMT3A	Unknown	36185232	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		EGFR	Unknown	26110571	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		ERCC2	Unknown	28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERG	Unknown	8022439	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		EWSR1	Unknown	8022439	Open Targets	Transcriptional misregulation in cancer
		FLI1	Unknown	8022439	Open Targets	Transcriptional misregulation in cancer
		IDH2	Unknown	36185232	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		JAK3	Unknown	26110571	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KIT	Unknown	37549909	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KRAS	Unknown	32918521 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		MAP2K1	Unknown	25202140 26980021 29768711 25899310 30923995 29649018 28481359 24982505	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP3K1	Unknown	25899310	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MET	Unknown	26110571 20519626	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		NOTCH1	Unknown	32918521 17874453	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NRAS	Unknown	36185232	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		PHOX2B	Unknown	28481359	Open Targets	—
		PIK3CA	Unknown	25858893 37874915	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R2	Unknown	25202140	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		STAG2	Unknown	28481359	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		TNFRSF14	Unknown	28481359	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TP53	Unknown	20519626	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more

Langerhans cell histiocytosis

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