Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
INFLAMMATORY BOWEL DISEASE	EFO_0003767 MONDO:0005265	TNFSF18	Unknown	17554261 18587394 23128233	GWAS catalog	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TNFSF8	Unknown	37262302	GWAS catalog	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TNRC18	Unknown	37156999	GWAS catalog	—
		TNXB	Unknown	37262302 37377963	GWAS catalog	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +3 more
		TOM1	Unknown	28067908	GWAS catalog	Neutrophil degranulation
		TOX	Unknown	36753304	GWAS catalog	—
		TRAF3IP2	Unknown	26192919 37156999 38616254	GWAS catalog	Cellular senescence IL-17 signaling pathway
		TRAIP	Unknown	39792054	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		TRAPPC10	Unknown	37156999	GWAS catalog	COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
		TRIM22	Unknown	—	GenCC	Interferon gamma signaling
		TRIM40	Unknown	38102678	GWAS catalog	—
		TRPM3	Unknown	32581322	GWAS catalog	TRP channels
		TRPS1	Unknown	37156999	GWAS catalog	—
		TSBP1	Unknown	37377963 38154582 39024449	GWAS catalog	—
		TSHZ2	Unknown	32581322	GWAS catalog	—
		TSPAN14	Unknown	23128233 26192919 28067908 37156999 38102678	GWAS catalog	Neutrophil degranulation Amyloid fiber formation
		TTC33	Unknown	17447842 17554261 17554300 17684544 18587394 21102463 22412388 22936669 23128233 26192919 26278503 28067908 33600772 33608531 37156999 37523193 37965154 39792054	GWAS catalog	—
		TUBD1	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	Motor proteins
		TUFM	Unknown	39792054	GWAS catalog	—
		TWF1	Unknown	27569725	GWAS catalog	—
		TYK2	Unknown	21102463 26192919 33608531 37156999 38102678	GWAS catalog	Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway +28 more
		UBA7	Unknown	39792054	GWAS catalog	Ubiquitin mediated proteolysis Parkinson disease Pathways of neurodegeneration - multiple diseases +5 more
		UBAC2	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	—
		UBASH3A	Unknown	37262302	GWAS catalog	—
		UBE2L3	Unknown	21102463 23128233 26192919 28067908 37156999 37523193 39792054	GWAS catalog	Ubiquitin mediated proteolysis Parkinson disease Pathways of neurodegeneration - multiple diseases +3 more
		UBE2V2	Unknown	26192919 28067908 37156999	GWAS catalog	Shigellosis Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) +5 more
		UBE3D	Unknown	26891255	GWAS catalog	Antigen processing: Ubiquitination & Proteasome degradation
		UBR4	Unknown	35232999	GWAS catalog	Human papillomavirus infection Viral carcinogenesis Neutrophil degranulation +1 more
		USP1	Unknown	26192919	GWAS catalog	Fanconi anemia pathway Recognition of DNA damage by PCNA-containing replication complex Fanconi Anemia Pathway
		USP34	Unknown	37262302	GWAS catalog	TCF dependent signaling in response to WNT Ub-specific processing proteases
		VSTM2B	Unknown	32581322	GWAS catalog	—
		VSX2	Unknown	28008999	GWAS catalog	—
		WDFY4	Unknown	28506689	GWAS catalog	—
		WDR46	Unknown	37377963	GWAS catalog	Major pathway of rRNA processing in the nucleolus and cytosol
		WWOX	Unknown	37156999	GWAS catalog	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
		XPO1	Unknown	37262302	GWAS catalog	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YDJC	Unknown	37156999	GWAS catalog	—
		ZBTB38	Unknown	26192919 28067908 37156999 37523193	GWAS catalog	—
		ZBTB40	Unknown	23128233 26192919 28067908 33608531 37156999 38616254	GWAS catalog	—
		ZBTB46	Unknown	37523193 39792054	GWAS catalog	—
		ZC3H13	Unknown	35232999	GWAS catalog	—
		ZFP36L1	Unknown	21102463 23128233 26192919 37156999	GWAS catalog	Cellular senescence Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
		ZFP36L2	Unknown	39792054	GWAS catalog	Cellular senescence
		ZFP90	Unknown	37156999	GWAS catalog	Generic Transcription Pathway
		ZGPAT	Unknown	18758464 21102463 23128233 26192919 39792054	GWAS catalog	—
		ZHX3	Unknown	37156999	GWAS catalog	—
		ZMIZ1	Unknown	19915574 21102463 23128233 25489960 26192919 28067908 37156999 39792054	GWAS catalog	—
		ZNF300	Unknown	23128233 26192919 28067908 37156999 39792054	GWAS catalog	Generic Transcription Pathway
		ZNF568	Unknown	37156999	GWAS catalog	Generic Transcription Pathway
		ZNF831	Unknown	23128233 26192919 28067908 37156999	GWAS catalog	—
INFLAMMATORY BOWEL DISEASES	C0021390	TRIM22	Unknown	—	Disgenet	Interferon gamma signaling
TRIM22-RELATED INFLAMMATORY BOWEL DISEASE	597201 C5680271	TRIM22	Unknown	26836588 32463623	Disgenet, Orphanet	Interferon gamma signaling

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