Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Immunoblastic Lymphadenopathy	EFO_1001350	ABL1	Unknown	24345752	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ALDH2	Unknown	24584070	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALK	Unknown	24413734	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	27203213	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		APC	Unknown	24345752	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ARID1A	Unknown	24345752	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	27203213 24345752	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASXL1	Unknown	24345752	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	27203213 29386642 28481359 24345752	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		B2M	Unknown	27203213	Open Targets	Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection +14 more
		BCL10	Unknown	24345752	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCORL1	Unknown	27203213	Open Targets	Polycomb repressive complex
		BCR	Unknown	27203213 24345752	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BMP5	Unknown	24584070	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway
		BRAF	Unknown	33739791 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		CARD11	Unknown	27203213	Open Targets	NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway +4 more
		CCND3	Unknown	24345752	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +17 more
		CD28	Unknown	27369867 24584070 24413734	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production +16 more
		CDK12	Unknown	36012614	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDKN1B	Unknown	27369867	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	27369867	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHEK2	Unknown	27203213 24413734	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CIC	Unknown	27203213	Open Targets	Spinocerebellar ataxia
		CNOT3	Unknown	27203213	Open Targets	RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		CREB1	Unknown	24413734	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis +53 more
		CREBBP	Unknown	27369867 28481359 24345752	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CSF1R	Unknown	24584070	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CTCF	Unknown	24345752	Open Targets	—
		CTNNB1	Unknown	27369867 24584070	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DDR2	Unknown	27203213	Open Targets	Non-integrin membrane-ECM interactions
		DDX3X	Unknown	33739791	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DICER1	Unknown	36012614	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNMT3A	Unknown	31394087 28148900 33739791 35846192 24413737 29662631 22216861 27369867 29386642 28481359 24345752 26268241	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ECT2L	Unknown	24345752	Open Targets	—
		EGFR	Unknown	28481359 36353546	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EP300	Unknown	27203213 24345752	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		ETV6	Unknown	24345752	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EZH2	Unknown	24584070 33739791	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		FANCG	Unknown	27203213	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAS	Unknown	24345752	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT1	Unknown	28481359	Open Targets	—
		FAT4	Unknown	24584070	Open Targets	Hippo signaling pathway - multiple species
		FBXO11	Unknown	24345752	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	24345752	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR4	Unknown	27203213	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FKBP9	Unknown	24584070	Open Targets	—
		FLT4	Unknown	27203213	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		GNAQ	Unknown	27203213 24584070	Open Targets	Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway +52 more
		GTF2I	Unknown	27369867	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		H3-3A	Unknown	27203213	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +18 more

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Immunoblastic lymphadenopathy

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