Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
Immunoblastic Lymphadenopathy	EFO_1001350	HGF	Unknown	24584070	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HNF1A	Unknown	27203213	Open Targets	Maturity onset diabetes of the young
		IDH2	Unknown	31394087 28148900 33739791 35846192 26617922 24413737 27369867 29662631 22215888 36353546 32476550 36012614 24584070 20861910 28481359 24345752 26268241	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF1	Unknown	24345752	Open Targets	—
		JAK1	Unknown	27369867 36353546 24345752 29662631	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	24345752	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	24345752	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KDM5C	Unknown	27203213	Open Targets	HDMs demethylate histones
		KIT	Unknown	24345752	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	24345752	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	27203213 24584070	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	27203213 24345752	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	24345752	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS2	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LRIG3	Unknown	24413734	Open Targets	—
		MAX	Unknown	27203213	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MED12	Unknown	28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MPL	Unknown	27203213	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH6	Unknown	24345752	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	27369867	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		NOTCH1	Unknown	27203213 22116551 28481359 24345752	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	27203213	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		PDE4DIP	Unknown	24584070	Open Targets	—
		PDGFRB	Unknown	27203213 24345752	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PHF6	Unknown	24345752	Open Targets	ATP-dependent chromatin remodeling
		PIK3R2	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		PLCG1	Unknown	27369867 24584070 25304611 29662631 28148900	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PRDM1	Unknown	24345752	Open Targets	Regulation of TP53 Expression
		PRKCB	Unknown	30097855	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PTEN	Unknown	27203213 29662631	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRT	Unknown	28481359	Open Targets	—
		RB1	Unknown	29662631	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	27203213	Open Targets	—
		RECQL4	Unknown	27203213	Open Targets	—
		REL	Unknown	28481359 24345752	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	28481359	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RHOA	Unknown	31394087 24413734 28148900 33739791 26617922 24413737 27369867 29662631 36353546 32476550 24786457 27203213 24584070 36012614 26574844 27158755 28481359 26268241	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RMI2	Unknown	28481359	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF213	Unknown	24345752	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		ROS1	Unknown	28481359	Open Targets	—
		SETBP1	Unknown	27203213	Open Targets	—
		SETD2	Unknown	24345752	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	33739791	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SGK1	Unknown	24345752	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SH2B3	Unknown	24345752	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SMARCD1	Unknown	24584070	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SOCS1	Unknown	28481359	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SPEN	Unknown	27203213 28481359	Open Targets	Notch signaling pathway
		STAT3	Unknown	24345752	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STK11	Unknown	27203213	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more

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Immunoblastic lymphadenopathy

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