Hepatosplenic t-cell lymphoma | Gene-Disease Associations & Pathways | GeDiPNet

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Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
hepatosplenic T-cell lymphoma	MONDO_0019474	AMER1	Unknown	27203213	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		AR	Unknown	24825865 27203213	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARAF	Unknown	24825865 27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		BCR	Unknown	24825865 27203213	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BRD3	Unknown	24825865 27203213	Open Targets	—
		BRD4	Unknown	24825865 27203213	Open Targets	—
		CREBBP	Unknown	24825865 26437031 27203213	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		DNMT3A	Unknown	26437031 26574607 26880370 27203213 32843425 33562071	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		ETV1	Unknown	26437031 27203213	Open Targets	Transcriptional misregulation in cancer
		GATA1	Unknown	26437031 27203213	Open Targets	RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Factors involved in megakaryocyte development and platelet production
		KDM6A	Unknown	24825865 26437031 27203213	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		LATS2	Unknown	24825865 27203213	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		MAP2K1	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MPL	Unknown	27203213	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		NUP214	Unknown	26437031 27203213	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		PIK3R2	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		POLE	Unknown	26437031 27203213	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPP2R1A	Unknown	27203213	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		RAD51C	Unknown	27203213	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RBM10	Unknown	26437031 27203213	Open Targets	—
		RET	Unknown	27203213	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		SRC	Unknown	27203213	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		STAT5B	Unknown	24825865 24947020 25586472 26917488 27203213	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		TP63	Unknown	27203213	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		WAS	Unknown	27203213	Open Targets	Chemokine signaling pathway Adherens junction Tight junction +7 more