Hepatocellular carcinoma | Gene-Disease Associations & Pathways | GeDiPNet

GeDiPNet

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Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HEPATOCELLULAR CARCINOMA	114550 HP:0001402 MONDO:0007256 EFO_0000182	APC	Causal	15608678 12101426 16650523 10987270 9927037	ClinVar, HPO	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN1	Causal	12101426 10987270 9927037 15608678 16650523	ClinVar, HPO	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		C2	Causal	21105107	GWAS catalog	Complement and coagulation cascades Alcoholic liver disease Pertussis +6 more
		CASP8	Causal	33893285 34290314	ClinVar, GWAS catalog, HPO	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CTNNB1	Causal	12375019 31189995 15305374 10665646 17187432 9635572 12439747 28302680 37160416 20347502 18467159 27100093 10487827 11375957 11477549 17393110 12845670 18171349 25536643 27984126 27588476 22180306 17531558 25016225 11282485 30977242 14515405 20923573	ClinVar, HPO	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DYSF	Causal	29385134	GWAS catalog	Smooth Muscle Contraction
		FGFR2	Causal	34290314 37340002	GWAS catalog	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		IGF2R	Causal	—	ClinVar, HPO	Virion - Herpesvirus Lysosome Endocytosis +5 more
		MET	Causal	10987270 9927037 12101426 15608678 16650523	ClinVar, HPO	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		PALB2	Causal	34290314	GWAS catalog	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PIK3CA	Causal	12101426 9927037 15608678 10987270 16650523	ClinVar, HPO	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		TERT	Causal	34290314 35788059	GWAS catalog	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TP53	Causal	28346444	ClinVar, GWAS catalog, HPO	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more