Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
CARCINOMA, HEPATOCELLULAR	MESH:D006528	A2M	Unknown	15509519	CTD	Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation +3 more
		AADAT	Unknown	28284560	CTD	Lysine degradation Tryptophan metabolism Metabolic pathways +3 more
		ABCB1	Unknown	17510421	CTD	ABC transporters Bile secretion MicroRNAs in cancer +2 more
		ABCB4	Unknown	22022477	CTD	ABC transporters Bile secretion PPARA activates gene expression +2 more
		ACACA	Unknown	21147110	CTD	Fatty acid biosynthesis Pyruvate metabolism Propanoate metabolism +12 more
		ACE	Unknown	16328049	CTD	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ACKR5	Unknown	28284560	CTD	—
		ACLY	Unknown	21147110	CTD	Citrate cycle (TCA cycle) Metabolic pathways ChREBP activates metabolic gene expression +2 more
		ACO2	Unknown	21472284	CTD	Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism Metabolic pathways +4 more
		ACOX1	Unknown	12771043 15565109	CTD	Fatty acid degradation beta-Alanine metabolism alpha-Linolenic acid metabolism +13 more
		ACSL4	Unknown	19363144	CTD	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ACTB	Unknown	19363144 21472284	CTD	ATP-dependent chromatin remodeling Rap1 signaling pathway Phagosome +54 more
		ADAMTS1	Unknown	19514085	CTD	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADAMTS13	Unknown	28284560	CTD	Platelet activation Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADD1	Unknown	19363144	CTD	Caspase-mediated cleavage of cytoskeletal proteins XBP1(S) activates chaperone genes Miscellaneous transport and binding events
		ADGRG7	Unknown	28284560	CTD	—
		ADH4	Unknown	28284560	CTD	Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism +8 more
		ADRA1A	Unknown	28284560	CTD	Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction +8 more
		ADRA2B	Unknown	28284560	CTD	cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +4 more
		AFP	Unknown	15276417 24012840 28284560 32961231 9029167	CTD	Hippo signaling pathway Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
		AKR1A1	Unknown	32805337	CTD	Glycolysis / Gluconeogenesis Pentose and glucuronate interconversions Ascorbate and aldarate metabolism +7 more
		AKR1B10	Unknown	21472284	CTD	Pentose and glucuronate interconversions Fructose and mannose metabolism Galactose metabolism +4 more
		AKR1C2	Unknown	21472284	CTD	Steroid hormone biosynthesis Metabolic pathways Chemical carcinogenesis - DNA adducts +4 more
		AKT1	Unknown	32045588	CTD	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		ANGPTL6	Unknown	28284560	CTD	—
		ANLN	Unknown	28284560	CTD	—
		ANXA4	Unknown	21472284	CTD	—
		APC	Unknown	—	CTD	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		APCS	Unknown	19363144	CTD	Amyloid fiber formation
		APEX1	Unknown	25109342	CTD	Base excision repair Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair +4 more
		APLN	Unknown	28284560	CTD	Neuroactive ligand-receptor interaction Apelin signaling pathway Peptide ligand-binding receptors +1 more
		APOA1	Unknown	21472284	CTD	PPAR signaling pathway Fat digestion and absorption Vitamin digestion and absorption +19 more
		APOF	Unknown	28284560	CTD	LDL remodeling
		AR	Unknown	18639551	CTD	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGAP11A	Unknown	28284560	CTD	Rho GTPase cycle
		ARHGEF39	Unknown	28284560	CTD	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARID1A	Unknown	22561517 22634756 22922871	CTD	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	22634756	CTD	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	21822264 22634756	CTD	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ARID3A	Unknown	35179300	CTD	TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
		ASF1B	Unknown	28284560	CTD	—
		ASPG	Unknown	28284560	CTD	Aspartate and asparagine metabolism
		AXIN1	Unknown	25822088	CTD	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		CASP8	Unknown	—	CTD	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CTNNB1	Unknown	20118494 21147764 25822088 27738331 28284560	CTD	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		IGF2R	Unknown	15057872	CTD	Virion - Herpesvirus Lysosome Endocytosis +5 more
		MET	Unknown	32045588	CTD	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		PIK3CA	Unknown	—	CTD	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		TERT	Unknown	16651430 22634754 25362482 25822088	CTD	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TP53	Unknown	17191126 18477611 22675488 25822088 8033108 9029167	CTD	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
HEPATOCELLULAR CARCINOMA	114550 HP:0001402 MONDO:0007256 EFO_0000182	APC	Causal	15608678 12101426 16650523 10987270 9927037	ClinVar, HPO	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN1	Causal	12101426 10987270 9927037 15608678 16650523	ClinVar, HPO	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		CASP8	Causal	33893285 34290314	ClinVar, GWAS catalog, HPO	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CTNNB1	Causal	12375019 31189995 15305374 10665646 17187432 9635572 12439747 28302680 37160416 20347502 18467159 27100093 10487827 11375957 11477549 17393110 12845670 18171349 25536643 27984126 27588476 22180306 17531558 25016225 11282485 30977242 14515405 20923573	ClinVar, HPO	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		IGF2R	Causal	—	ClinVar, HPO	Virion - Herpesvirus Lysosome Endocytosis +5 more
		MET	Causal	10987270 9927037 12101426 15608678 16650523	ClinVar, HPO	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		PIK3CA	Causal	12101426 9927037 15608678 10987270 16650523	ClinVar, HPO	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		TERT	Causal	34290314 35788059	GWAS catalog	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TP53	Causal	28346444	ClinVar, GWAS catalog, HPO	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more

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Hepatocellular carcinoma

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