Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
GRAVES DISEASE	C0018213 EFO_0004237 MESH:D006111	IL23R	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +4 more
		IL2RA	Unknown	22922229	GWAS catalog	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Endocytosis +12 more
		IL3	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Apoptosis +11 more
		IL4	Unknown	33132244	CTD, Disgenet	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +15 more
		IL6	Unknown	16372246	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		IL6R	Unknown	16372246	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +13 more
		ITPR3	Unknown	21900946	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway Phosphatidylinositol signaling system +52 more
		JAZF1	Unknown	34594039	GWAS catalog	—
		LPP	Unknown	22922229 32514122 34594039	GWAS catalog	—
		LSAMP	Unknown	38534778	GWAS catalog	Post-translational modification: synthesis of GPI-anchored proteins
		LTA	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway +7 more
		MAGT1	Unknown	34594039	GWAS catalog	N-Glycan biosynthesis Various types of N-glycan biosynthesis Protein processing in endoplasmic reticulum +3 more
		MMEL1	Unknown	22922229	GWAS catalog	—
		MTHFR	Unknown	—	Disgenet	One carbon pool by folate Metabolic pathways Antifolate resistance +2 more
		MUC22	Unknown	21900946	GWAS catalog	—
		MYL2	Unknown	32514122	GWAS catalog	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Apelin signaling pathway +12 more
		NTN1	Unknown	38534778	GWAS catalog	Axon guidance Netrin-1 signaling DCC mediated attractive signaling
		OGG1	Unknown	—	Disgenet	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +7 more
		P2RY10	Unknown	34594039	GWAS catalog	Neuroactive ligand-receptor interaction G alpha (q) signalling events P2Y receptors
		PCLO	Unknown	39024449	GWAS catalog	Insulin secretion
		PDCD1	Unknown	33132244	CTD, Disgenet	Cell adhesion molecules T cell receptor signaling pathway PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		PRICKLE1	Unknown	22922229	GWAS catalog	Wnt signaling pathway Asymmetric localization of PCP proteins
		PRR3	Unknown	21900946	GWAS catalog	—
		PRSS36	Unknown	22922229	GWAS catalog	—
		PTPN22	Unknown	21190368 22922229 34594039	CTD, Disgenet, GWAS catalog	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
		RHOH	Unknown	21841780 34594039	GWAS catalog	Leukocyte transendothelial migration Salmonella infection Rho GTPase cycle
		RNASET2	Unknown	21841780	CTD, Disgenet, GWAS catalog	Neutrophil degranulation
		SERPINE1	Unknown	—	Disgenet	HIF-1 signaling pathway p53 signaling pathway Cellular senescence +10 more
		SETD1A	Unknown	34594039	GWAS catalog	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SLAMF6	Unknown	23612905 32514122 34594039	GWAS catalog	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
		SLC25A27	Unknown	25429627	GWAS catalog	The fatty acid cycling model The proton buffering model
		STAT4	Unknown	34594039	GWAS catalog	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +9 more
		TAF9B	Unknown	34594039	GWAS catalog	Basal transcription factors Ub-specific processing proteases RNA Polymerase II Pre-transcription Events +5 more
		TCP11	Unknown	34594039	GWAS catalog	—
		TG	Unknown	23612905 33132244	CTD, Disgenet, GWAS catalog	Thyroid hormone synthesis Autoimmune thyroid disease
		TGFB1	Unknown	33132244	CTD, Disgenet	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +49 more
		TNF	Unknown	—	Disgenet	Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +72 more
		TNFRSF8	Unknown	16372246	CTD, Disgenet	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TNFSF8	Unknown	16372246	CTD, Disgenet	Cytokine-cytokine receptor interaction TNFs bind their physiological receptors
		TP53	Unknown	—	Disgenet	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TPO	Unknown	33132244	CTD, Disgenet	Tyrosine metabolism Metabolic pathways Thyroid hormone synthesis +2 more
		TSBP1	Unknown	21900946	GWAS catalog	—
		TSHB	Unknown	33132244	CTD, Disgenet	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +8 more
		TSHR	Unknown	1955520 21841780 22922229 32514122 34594039 39024449	CTD, Disgenet, GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		UBASH3A	Unknown	34594039	GWAS catalog	—
		VANGL2	Unknown	32514122 34594039	GWAS catalog	Wnt signaling pathway
		VAV3	Unknown	25429627	GWAS catalog	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +23 more
		VDR	Unknown	—	Disgenet	Parathyroid hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Mineral absorption +5 more
		VEGFA	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more

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Graves disease

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