Gastrointestinal villous adenoma

cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Cytoskeleton in muscle cells Insulin secretion Thyroid hormone synthesis Thyroid hormone signaling pathway Aldosterone synthesis and secretion Aldosterone-regulated sodium reabsorption Endocrine and other factor-regulated calcium reabsorption Proximal tubule bicarbonate reclamation Salivary secretion Gastric acid secretion Pancreatic secretion Carbohydrate digestion and absorption Protein digestion and absorption Bile secretion Mineral absorption Ion homeostasis Ion transport by P-type ATPases +18 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Adrenergic signaling in cardiomyocytes Aldosterone synthesis and secretion Endocrine and other factor-regulated calcium reabsorption Salivary secretion Pancreatic secretion Mineral absorption Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +9 more

Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling Neutrophil degranulation Interferon gamma signaling Modulation by Mtb of host immune system Amyloid fiber formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC +14 more

Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) UCH proteinases Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +11 more

Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex

Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Fluid shear stress and atherosclerosis Signaling by BMP +4 more

Platinum drug resistance MAPK signaling pathway p53 signaling pathway Efferocytosis Apoptosis Apoptosis - multiple species Cytosolic DNA-sensing pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway TNF signaling pathway Serotonergic synapse Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Salmonella infection Pertussis Legionellosis Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Small cell lung cancer Viral myocarditis Lipid and atherosclerosis Activation of caspases through apoptosome-mediated cleavage Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Apoptosis induced DNA fragmentation Signaling by Hippo NADE modulates death signalling Caspase-mediated cleavage of cytoskeletal proteins Apoptotic cleavage of cell adhesion proteins Caspase activation via Dependence Receptors in the absence of ligand Other interleukin signaling +53 more

Platinum drug resistance p53 signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Salmonella infection Legionellosis Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Viral myocarditis Lipid and atherosclerosis Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 +53 more

Ubiquitin mediated proteolysis Endocytosis

Cell cycle Oocyte meiosis p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Cushing syndrome Hepatitis B Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Prostate cancer Small cell lung cancer Gastric cancer G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition G1/S-Specific Transcription p53-Dependent G1 DNA Damage Response PTK6 Regulates Cell Cycle +24 more

Cell adhesion molecules PD-L1 expression and PD-1 checkpoint pathway in cancer PD-1 signaling

Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins +3 more

Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway Cell adhesion molecules Adherens junction Bacterial invasion of epithelial cells Pathways in cancer Endometrial cancer Thyroid cancer Melanoma Bladder cancer Gastric cancer Degradation of the extracellular matrix Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells +15 more

Adherens junctions interactions

Adherens junctions interactions

Endocrine resistance Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Tight junction T cell receptor signaling pathway AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Hepatitis C Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Pancreatic cancer Glioma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma SCF(Skp2)-mediated degradation of p27/p21 Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence RMTs methylate histone arginines Transcriptional regulation of white adipocyte differentiation Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional regulation by RUNX2 Transcriptional regulation of granulopoiesis Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 +40 more

Endocrine resistance Platinum drug resistance Cell cycle p53 signaling pathway Cellular senescence Cushing syndrome Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Pancreatic cancer Glioma Melanoma Bladder cancer Chronic myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Apoptotic factor-mediated response Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors Regulation of TP53 Degradation Cyclin D associated events in G1 Stabilization of p53 Transcriptional Regulation by VENTX Regulation of RUNX3 expression and activity Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function Evasion of Oncogene Induced Senescence Due to p14ARF Defects Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects +33 more

Gastric cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)

Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2 +6 more

Anchoring of the basal body to the plasma membrane

ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis HDACs deacetylate histones Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription NGF-stimulated transcription +5 more

Cell cycle p53 signaling pathway Cellular senescence Human T-cell leukemia virus 1 infection Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex +9 more

Lysosome Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Huntington disease Bacterial invasion of epithelial cells Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance +18 more

Lysosome Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Huntington disease Bacterial invasion of epithelial cells Gap junction degradation Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis +8 more

RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Signaling by FGFR1 in disease AURKA Activation by TPX2 +6 more

Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Protein digestion and absorption Amoebiasis Diabetic cardiomyopathy Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization +16 more

cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Adrenergic signaling in cardiomyocytes Osteoclast differentiation Antigen processing and presentation TNF signaling pathway Circadian rhythm Circadian entrainment Thermogenesis Cholinergic synapse Dopaminergic synapse Insulin secretion Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Insulin resistance Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Huntington disease Prion disease Cocaine addiction Amphetamine addiction Alcoholism Tuberculosis Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Viral carcinogenesis Chemical carcinogenesis - receptor activation Prostate cancer AKT phosphorylates targets in the nucleus CREB phosphorylation Transcriptional activation of mitochondrial biogenesis NCAM signaling for neurite out-growth Circadian Clock CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling Constitutive Signaling by AKT1 E17K in Cancer Gastrin-CREB signalling pathway via PKC and MAPK NGF-stimulated transcription HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +53 more

cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Adrenergic signaling in cardiomyocytes TNF signaling pathway Thermogenesis Cholinergic synapse Dopaminergic synapse Insulin secretion Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Glucagon signaling pathway Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Insulin resistance Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Huntington disease Prion disease Cocaine addiction Amphetamine addiction Alcoholism Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis - receptor activation Prostate cancer +32 more

Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Interleukin-7 signaling

Spliceosome mRNA Splicing - Major Pathway

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway Osteoclast differentiation Hematopoietic cell lineage Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Other interleukin signaling Transcriptional Regulation by VENTX +10 more

Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells +3 more

Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic

NF-kappa B signaling pathway Necroptosis Osteoclast differentiation RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway TNF signaling pathway NOD1/2 Signaling Pathway TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Negative regulators of DDX58/IFIH1 signaling +9 more

Axon guidance Pathways in cancer Colorectal cancer Netrin-1 signaling DCC mediated attractive signaling Caspase activation via Dependence Receptors in the absence of ligand +3 more

Spliceosome Transcriptional misregulation in cancer Proteoglycans in cancer SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression +3 more

MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis

Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events +4 more

Hepatitis C L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit +4 more

Pre-NOTCH Transcription and Translation

MAPK signaling pathway Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer

Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events Transcription-Coupled Nucleotide Excision Repair (TC-NER) TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation +4 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Proteoglycans in cancer MicroRNAs in cancer Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +19 more

MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Amyotrophic lateral sclerosis Proteoglycans in cancer Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Estrogen-dependent gene expression Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +22 more

Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE +19 more

Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER +1 more

Endocrine resistance Hormone signaling Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Endocrine and other factor-regulated calcium reabsorption Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Breast cancer Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression +21 more

Transcriptional misregulation in cancer