Gastric neuroendocrine tumor g1

MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway Endocytosis Cellular senescence TGF-beta signaling pathway Osteoclast differentiation Hippo signaling pathway Adherens junction Th17 cell differentiation Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Chagas disease Hepatitis B Human T-cell leukemia virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Colorectal cancer Pancreatic cancer Chronic myeloid leukemia Hepatocellular carcinoma Gastric cancer Diabetic cardiomyopathy Downregulation of TGF-beta receptor signaling TGF-beta receptor signaling activates SMADs TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGFBR2 Kinase Domain Mutants in Cancer TGFBR1 KD Mutants in Cancer TGFBR1 LBD Mutants in Cancer +28 more

PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Human papillomavirus infection MicroRNAs in cancer Integrin cell surface interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +6 more

SUMOylation of DNA replication proteins

Endocrine resistance Platinum drug resistance MAPK signaling pathway Sphingolipid signaling pathway Cell cycle p53 signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Ferroptosis Cellular senescence Wnt signaling pathway Neurotrophin signaling pathway Thyroid hormone signaling pathway Parkinson disease Amyotrophic lateral sclerosis Huntington disease Shigellosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NOXA and translocation to mitochondria Activation of PUMA and translocation to mitochondria Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Oncogene Induced Senescence DNA Damage/Telomere Stress Induced Senescence SUMOylation of transcription factors Autodegradation of the E3 ubiquitin ligase COP1 TP53 Regulates Metabolic Genes Ub-specific processing proteases Ovarian tumor domain proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Expression Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation G2/M DNA damage checkpoint G2/M Checkpoints Stabilization of p53 Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint Transcriptional Regulation by VENTX RUNX3 regulates CDKN1A transcription Regulation of PTEN gene transcription +85 more

MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors +5 more

Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer Thyroid cancer ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events +27 more

Antigen processing: Ubiquitination & Proteasome degradation

Intraflagellar transport Intra-Golgi traffic

ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex Ub-specific processing proteases +1 more

Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Cellular senescence Thermogenesis Insulin signaling pathway Human cytomegalovirus infection Human papillomavirus infection Herpes simplex virus 1 infection Choline metabolism in cancer Macroautophagy Inhibition of TSC complex formation by PKB Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes TBC/RABGAPs +15 more

Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Cellular senescence Thermogenesis Insulin signaling pathway Thyroid hormone signaling pathway Human cytomegalovirus infection Human papillomavirus infection Herpes simplex virus 1 infection Choline metabolism in cancer Macroautophagy Inhibition of TSC complex formation by PKB AKT phosphorylates targets in the cytosol Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer TBC/RABGAPs +19 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Thyroid hormone synthesis Regulation of lipolysis in adipocytes Autoimmune thyroid disease Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +6 more

Ubiquitin mediated proteolysis

Ub-specific processing proteases

Mitophagy - animal Endocytosis Cushing syndrome Downregulation of ERBB2:ERBB3 signaling Regulation of FZD by ubiquitination Ub-specific processing proteases Negative regulation of MET activity +4 more

Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Peroxisomal protein import Amyloid fiber formation +2 more

Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway Focal adhesion Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Regulation of actin cytoskeleton Yersinia infection Proteoglycans in cancer Lipid and atherosclerosis GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Rho GTPase cycle Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +30 more

Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels

Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint +9 more

Transcriptional misregulation in cancer

Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 Influenza A Human T-cell leukemia virus 1 infection Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation +15 more

Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 Signaling by Hippo YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination +5 more

Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Neddylation Antigen processing: Ubiquitination & Proteasome degradation +2 more

Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription

Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease

Wnt signaling pathway Regulation of FZD by ubiquitination

mRNA Splicing - Minor Pathway